Liver Tumors and Liver Transplantation Flashcards
Most common indications for transplant
hep c, alcohol cirrhosis, cholestatic liver disease
Breakeven point for MELD score
if 15-17, new liver
T/F there are some exceptions to MELD
T –> when MELD does not adequately predict likelihood of death on waiting list
T/F living donor transplant has similar survival as deceased donor transplant
T –> benefit is no waiting time on list/no death while waiting
risk factors for hcc
hepb, c, aflatoxin b1 (mycotoxin of aspergillus –> mutation in p53)
Blood flow changes w/cancer
most blood comes from hepatic artery vs portal vein –>portal vein washout
Tx of hcc
radio frequency ablation, direct chemotherapy to hepatic artery –> selectively kills tumor vs portal vein backup to liver, sorafenib
Transplant criteria for hcc
no lymphovascular spread, no extrahepatic spread, sizing/#
