Dilemmas in Pediatric Nutrition Flashcards
1
Q
Role of vitamin C
A
cofactor in hydroxylation of proline/lysine in formation of collagen, protects against ROS damage, increase iron absorption
2
Q
Signs and Symptoms of Rickets
A
hypotonia, muscle weakness, tetany, seizures, bone pain, motor development delays, poor growth, bowed legs, delayed tooth eruption, infection risk, etc
3
Q
Vitamin D activation
A
uvb –> skin –> D3 (cholecalciferol) + D3 and D2 (Ergocalciferol) from diet –> liver hydroxylase –> PTH mediated kidney hydroxylase –> intestine calcium etc.
4
Q
Which vitamin d is measured in serum
A
liver hydroxylase product = 25(OH)D –> longest half life
5
Q
Sequelae of Vitamin D deficiency
A
rickets, osteomalacia, osteoporosis, fractures, cancers, MS, T1D, crohns, respiratory infection, heart disease
