Liver symposium

Question 1

Which Hep’s are parenteral viruses and cause chronic disease?

Answer 1

B
C
D

Question 2

Which hep’s are enteric viruses and cause self-limiting, acute infections?

Answer 2

A

E

Question 3

How many people die each year from viral hepatitis?

Answer 3

1 million

Question 4

How may Hep A transmit?

Answer 4

Faecal-oral
Sexual
Blood

Question 5

Can hep A often be asymptomatic?

Answer 5

Yes

Question 6

How is acute Hep A diagnosed?

Answer 6

IgM antibodies

Question 7

What causes Hep A

Answer 7

Exposure to Hepatovirus A (HAV)

Occupational
Male-male sex
Haemophiliacs

Question 8

What causes Hep B?

Answer 8

HBV

Question 9

What does HBV contain?

Answer 9

Hep surface antigen HBsAg
Hep E antigen HBeAg
Hep core antigen HBcAg

Question 10

How are Hep B and Hep C treated?

Answer 10

Pegylated interferon

Oral antiviral

Question 11

Would Hep C affect LFT’s?

Answer 11

LFT may be normal in Hep C

Question 12

How does Hep D respond to treatment?

Answer 12

Very resistant

Question 13

How does Hep E resolve?

Answer 13

Self limiting

Currently no effective vaccine available

Question 14

What are the 3 components of NAFLD?

Answer 14

Simple steatosis
Non-alcoholic steatohepatitis
Fibrosis and cirrhosis

Question 15

What conditions are often associated with NAFLD?

Answer 15

DM
Obesity
Hypertriglyceridaemia
Hypertension

Question 16

What are the main risk factors for NAFLD?

Answer 16

Age
Ethnicity (Hispanics)
Genetic

Question 17

Which tests may be useful in the diagnosis of NAFLD?

Answer 17

Enhanced Liver Fibrosis panel (ELF)
Cytokeratin-18
Ultrasound
Fibroscan
MR spectroscopy
CT
Biopsy

Question 18

How is NAFLD?

Answer 18

Diet and weight reduction
Exercise
Insulin sensitisers like metformin
VitE

Question 19

What serum results would you see in autoimmune hepatitis?

Answer 19

IgG

Question 20

What 3 types of antibodies are present in autoimmune hepatitis?

Answer 20

SLA
LKM1
ANA
SMA

Question 21

How is autoimmune hepatitis treated?

Answer 21

Responds well to steroids

Long term azathioprine

Question 22

What are some contraindications to liver transplant?

Answer 22

Active extrahepatic malignancy
Hepatic malignancy with macrovascular or diffuse tumour invasion
Active and uncontrolled infection in the body
Active substance abuse
Psychological factors
Brian death

Question 23

What is diagnostic of Primary Biliary Cholangitis?

Answer 23

Elevated IgM

Anti-mitochondrial antibody positive

Question 24

What are some symptoms of primary biliary cholangitis?

Answer 24

Pruritis

Fatigue

Question 25

What is diagnostic of Primary Sclerosing Cholangitis?

Answer 25

pANCA positive

Question 26

How is primary sclerosing cholangitis treated?

Answer 26

Liver transplant

Biliary stents