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GI System > Liver symposium > Flashcards

Liver symposium Flashcards

1
Q

Which Hep’s are parenteral viruses and cause chronic disease?

A

B
C
D

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2
Q

Which hep’s are enteric viruses and cause self-limiting, acute infections?

A

A

E

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3
Q

How many people die each year from viral hepatitis?

A

1 million

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4
Q

How may Hep A transmit?

A

Faecal-oral
Sexual
Blood

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5
Q

Can hep A often be asymptomatic?

A

Yes

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6
Q

How is acute Hep A diagnosed?

A

IgM antibodies

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7
Q

What causes Hep A

A

Exposure to Hepatovirus A (HAV)

Occupational
Male-male sex
Haemophiliacs

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8
Q

What causes Hep B?

A

HBV

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9
Q

What does HBV contain?

A

Hep surface antigen HBsAg
Hep E antigen HBeAg
Hep core antigen HBcAg

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10
Q

How are Hep B and Hep C treated?

A

Pegylated interferon

Oral antiviral

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11
Q

Would Hep C affect LFT’s?

A

LFT may be normal in Hep C

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12
Q

How does Hep D respond to treatment?

A

Very resistant

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13
Q

How does Hep E resolve?

A

Self limiting

Currently no effective vaccine available

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14
Q

What are the 3 components of NAFLD?

A

Simple steatosis
Non-alcoholic steatohepatitis
Fibrosis and cirrhosis

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15
Q

What conditions are often associated with NAFLD?

A

DM
Obesity
Hypertriglyceridaemia
Hypertension

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16
Q

What are the main risk factors for NAFLD?

A

Age
Ethnicity (Hispanics)
Genetic

17
Q

Which tests may be useful in the diagnosis of NAFLD?

A 
Enhanced Liver Fibrosis panel (ELF)
Cytokeratin-18
Ultrasound
Fibroscan
MR spectroscopy
CT
Biopsy
18
Q

How is NAFLD?

A

Diet and weight reduction
Exercise
Insulin sensitisers like metformin
VitE

19
Q

What serum results would you see in autoimmune hepatitis?

A

IgG

20
Q

What 3 types of antibodies are present in autoimmune hepatitis?

A

SLA
LKM1
ANA
SMA

21
Q

How is autoimmune hepatitis treated?

A

Responds well to steroids

Long term azathioprine

22
Q

What are some contraindications to liver transplant?

A

Active extrahepatic malignancy
Hepatic malignancy with macrovascular or diffuse tumour invasion
Active and uncontrolled infection in the body
Active substance abuse
Psychological factors
Brian death

23
Q

What is diagnostic of Primary Biliary Cholangitis?

A

Elevated IgM

Anti-mitochondrial antibody positive

24
Q

What are some symptoms of primary biliary cholangitis?

A

Pruritis

Fatigue

25
Q

What is diagnostic of Primary Sclerosing Cholangitis?

A

pANCA positive

26
Q

How is primary sclerosing cholangitis treated?

A

Liver transplant

Biliary stents

GI System (20 decks)

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