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PHAR 123 > Liver Disease > Flashcards

Liver Disease Flashcards

1
Q

What is cirrhosis of the liver?

A

chronic, irreversible damage that impairs function (looks lumpy and hard)

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2
Q

Main causes of cirrhosis?

A

Hep BCD, NAFLD,alcohol=75%

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3
Q

What is Non-alcohol steatohepatitis (NASH)

A

more severe because more inflammation

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4
Q

What is the treatment for NAFLD

A

NONE- diet and exercise
lipid control

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5
Q

What is the pathogenesis of alcohol hepatitis

A

alcohol deposits fat b/c stops mitochondria
then lipids peroxidation= ROS
stims neutrophils= lots of cytokines like TNF alpha= fibrosis

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6
Q

WHat are the symptoms of cirrhosis

A

ascites-fluid in tummy b/c low flow
purpura=bruising-b/c low clotting factors
pitted edema
bad breath
jaundice
encephalopathy

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7
Q

Systemic symptoms of cirrhosis

A

bleed
HTN in liver
low hormones
increased toxins

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8
Q

Liver Function Tests

A

THESE SHOULD NOT BE IN BLOOD= they spew their contents
AST - if higher than ALT= Alcohol
ALT-more liver specific
albumin
bilirubin
PT

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8
Q

Liver Function Tests

A

THESE SHOULD NOT BE IN BLOOD= they spew their contents
AST - if higher than ALT= Alcohol
ALT-more liver specific
albumin
bilirubin
PT

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9
Q

What is the common cause of hepatocellular carcinoma

A

Hepatitis C

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10
Q

How to treat hepatocellular carcinoma

A

surgery
chemoembolism
radiation

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11
Q

What common metastasis ends up in the liver

A

colon cancer

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12
Q

How does cancer impact function

A

block function and pinch off flow

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13
Q

I have mild-moderate encephalopathy what is my score

A

2

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14
Q

I have no encephalopathy what is my score

A

1

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15
Q

I have severe encephalopathy what is my score

A

3

16
Q

I have mild-moderate (responds to diuretics) ascites what is my score

A

2

17
Q

I have <2 bilirubin what is my score

A

1

18
Q

I have 2-3 bilirubin what is my score

A

2

19
Q

I have >3 bilirubin what is my score

A

3

20
Q

I have >3.5 albumin what is my score

A

1

21
Q

I have 3.5-2.8 albumin what is my score

A

2

22
Q

I have <2.8 albumin what is my score

A

3

23
Q

If my total points is 5-6 what severity of liver disease do I have

A

not severe

24
Q

If my total points is 7-9 what severity of liver disease do I have

A

moderate

25
Q

If my total points is 10-15 what severity of liver disease do I have

A

BAD

PHAR 123 (18 decks)

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