Liver Disease Flashcards
What is cirrhosis of the liver?
chronic, irreversible damage that impairs function (looks lumpy and hard)
Main causes of cirrhosis?
Hep BCD, NAFLD,alcohol=75%
What is Non-alcohol steatohepatitis (NASH)
more severe because more inflammation
What is the treatment for NAFLD
NONE- diet and exercise
lipid control
What is the pathogenesis of alcohol hepatitis
alcohol deposits fat b/c stops mitochondria
then lipids peroxidation= ROS
stims neutrophils= lots of cytokines like TNF alpha= fibrosis
WHat are the symptoms of cirrhosis
ascites-fluid in tummy b/c low flow
purpura=bruising-b/c low clotting factors
pitted edema
bad breath
jaundice
encephalopathy
Systemic symptoms of cirrhosis
bleed
HTN in liver
low hormones
increased toxins
Liver Function Tests
THESE SHOULD NOT BE IN BLOOD= they spew their contents
AST - if higher than ALT= Alcohol
ALT-more liver specific
albumin
bilirubin
PT
Liver Function Tests
THESE SHOULD NOT BE IN BLOOD= they spew their contents
AST - if higher than ALT= Alcohol
ALT-more liver specific
albumin
bilirubin
PT
What is the common cause of hepatocellular carcinoma
Hepatitis C
How to treat hepatocellular carcinoma
surgery
chemoembolism
radiation
What common metastasis ends up in the liver
colon cancer
How does cancer impact function
block function and pinch off flow
I have mild-moderate encephalopathy what is my score
2
I have no encephalopathy what is my score
1
I have severe encephalopathy what is my score
3
I have mild-moderate (responds to diuretics) ascites what is my score
2
I have <2 bilirubin what is my score
1
I have 2-3 bilirubin what is my score
2
I have >3 bilirubin what is my score
3
I have >3.5 albumin what is my score
1
I have 3.5-2.8 albumin what is my score
2
I have <2.8 albumin what is my score
3
If my total points is 5-6 what severity of liver disease do I have
not severe
If my total points is 7-9 what severity of liver disease do I have
moderate
If my total points is 10-15 what severity of liver disease do I have
BAD
