CNS Pathology Introduction Flashcards
The average brain has over how many neurons? How many synaptic connections?
> 100 billion
150 trillion synaptic connections
The bones of the ______ & _________ protect the CNS from mechanical injury.
Skull ; Vertebrae
The _________ & the ___ separate the CNS from the remainder of the body.
Meninges ; BBB (Blood Brain Barrier)
What are the three classical features of Neurons?
-Nondividing
-Permanent
-Postmitotic
CNS disease symptoms result from what?
Dysfunction of or loss of Neuronal function
What % of total cardiac output goes to the brain?
15%
What % of total bodily oxygen consumption is conducted by the brain?
20%
What % of total bodily glucose consumption is conducted by the brain?
25%
The brain extracts approximately ___% of Oxygen & ___% of Glucose from Arterial Blood in order to facilitate active Neuronal Cells.
50% O2 ; 10% Glucose
Why are Neurons particularly vulnerable to the effects of toxins?
-Fatty nature of Neurons (many organotoxins are fat soluble)
-High activity levels & specialization
-High concentration of Sulfur-Containing AAs (which bind toxic heavy metals)
How do Neurons respond following brain tissue injury?
-Axon &/or Cell Body swell
-Rapid Death results in Phagocytosis (via transformed Microglia)
How do Oligodendroglia respond following brain tissue injury?
-DO NOT REGENERATE (!!)… These cells are typically responsible for myelinating neuronal cells, but do not regenerate upon being damaged.
How do Microglia respond following brain tissue injury?
-Chemotactic Factors activate them & cause them to transform into Phagocytic Cells.
How do Astrocytes respond following brain tissue injury?
-Hypertrophy / Hyperplasia (increase in size & number)… Rxn is called “Gliosis”.
How do Ependymal Cells respond following brain tissue injury?
-DO NOT REGENERATE (!!)… Typically line the ventricles of the brain, but do not regenerate upon being damaged (much like Oligodendroglia).
What differs in the presentation of acute brain injury (vs. damage to other bodily compartments)?
No Fibrotic Scarring (a hole is left instead)
Summarize the “Ischemic Cascade”.
1) Cerebral Blood Flow & Metabolic Demands are mismatched… Can bring about either Electrical Failures or induce Anaerobic Metabolism to kick in.
2) Electric Fail: Na+ Influx into Neurons (ie. Neuron Depolarization) stimulates Ca2+ Influx, leading to activated PLA2. PLA2 enzyme converts membrane phospholipids into Arachidonic Acid, which stimulates both the Cyclooxygenase & Lipooxygenase Pathways. COX Pathway activation leads to Potent Vasoconstriction & Platelet Aggregation, as well as Free Radical production. LPOX Pathway activation induces LT production, which promotes inflammatory response & brings about neuron damage.
3) Anaerobic Metabolism Activation: Induces Lactic Acidosis, as Ketone Bodies are being produced as alternative energy sources. The production of these Ketones causes neuronal damage.
What does “Global Ischemia” mean?
Not enough O2 gets to brain tissues (ie. CHF / ASCVD)
What does “Cerebral Infarct” mean?
-Just means cell death in brain adam
:( the below part is what causes it
Blood Vessel bursts or leaks (Hemorrhagic)
-Blood Vessel blocked by a blood clot, plaque, embolism (Ischemic)