Drug Induced Liver Injury

Question 1

What is the most common overdose of a drug that causes liver injury

Answer 1

acetaminophen

Question 2

True or false medications only cause liver injury at toxic doses

Answer 2

FALSE

Question 3

Most common drugs that cause liver injury at therapeutic doses

Answer 3

antimicrobials

Question 4

factors that increase risk of DILI

Answer 4

lipophilicity
dose- dose related
idiosyncratic= not related to dose
lifesyle
age
sex
infections

Question 5

What is the most common cause of ACUTE liver failure

Answer 5

drugs

Question 6

What causes zonal hepatic necrosis

Answer 6

acetaminophen and mushrooms

Question 7

What causes cholestasis

Answer 7

estrogen, SMX

Question 8

What causes acute hepatitis

Answer 8

antibiotics

Question 9

How to treat DILI

Answer 9

STOP FUCKING DRUG IDIOT

Question 10

What is the classification of mild increase of liver enzymes

Answer 10

<300= can mean any liver issue

Question 11

What is the classifcation of very high liver enzymes

Answer 11

> 500= in actor hepatitis or acet tox

Question 12

T/F a fall in liver enzymes to normal is always good

Answer 12

NO-if theres an increase in bilirubin, and PT= liver failure

Question 13

WHat enzymes indicated cholestasis

Answer 13

ALk. Phos
GGT

Question 14

IN liver injury what would be the effect on prothrombin time

Answer 14

would increase because the liver cant make clotting factors

Question 15

What is the dose possible for fatality for acet per kg

Answer 15

200mg/kg

Question 16

How to treat acetaminophen overdose

Answer 16

N-acetylcysteine

Question 17

What are the stages of acetaminophen posioning

Answer 17

1= NDV, sweat
2- pain and Increase in enzymes
3- rapid fail
4-recovery