Blood Flashcards

1
Q

What is the biggest part of blood?

A

plasma 55%=mostly water
cells= 45%

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2
Q

Where does hematopoiesis happen

A

red bone marrow= adult has it in sternum and hip

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3
Q

where does warfarin act

A

activation of factor IX, VII, X, II
1972 Canada vs soviet (Vit K factors)

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4
Q

Where does Apixaban’s act

A

Xa

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5
Q

Where does the intrinsic and extrinsic pathway connect

A

factor x activation

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6
Q

Where do heparins act

A

XA and IIA

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7
Q

Where do dabigatran’s act

A

activation of factor II

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8
Q

Which factor does LWMH act?

A

more for XA than IIA

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9
Q

How do antiplatelets work

A

COX inhibitor
stop aggregation or production
Grel’s, asprin

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10
Q

How do antiplatelets work

A

COX inhibitor
stop aggregation or production
Grel’s, asprin

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11
Q

What does thrombin do

A

generates fibrin to give structural integrity
factor IIA

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12
Q

How to get rid of clot

A

tPA activates plasminogen to lyse clot

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13
Q

What is the classification of anemia

A

<13g/dl for men
<1.5g/dl

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14
Q

Causes of anemia

A

bad production- cancer, low amount
destroying- because bad shape
bleed

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15
Q

Causes of anemia

A

bad production- cancer, low amount
destroying- because bad shape
bleed

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16
Q

What is normocyitc anemia

A

normal chape but low amount

17
Q

What is microcytic anemia

A

shrink= low Iron**

18
Q

What is macrocytic anemia

A

big caused by low B12 or folate

19
Q

Symptoms of anemia

A

yellow eyes RED IF SEVERE
pale cold, faint, chest pain, angina, low BP, tachycardia

20
Q

Some causes of low hematopoeisis

A

low nutrients, bone marrow failure= aplastic anemia

21
Q

what does intracorpuscular mean and give examples

A

inside cell so structural deformaties

22
Q

What does extracorpuscular mean and give examples

A

caused by not cell, so like antibodies, virus

23
Q

What is the most common form of anemia

A

low iron

24
Q

What does folate do

A

works with vitamin C and B12 to make RBC and WBC
water sol so no storage

25
Q

What causes decreased folate

A

alcohol, overcook veggies, dialysis

26
Q

What are the WBC disorders

A

leukocytosis
neutropenia
lymphocytosis
lymphopenia

27
Q

What conditions increase WBC

A

infections, inflammation, stress, exercise

28
Q

What conditions decrease WBC

A

antiimmune drugs, antibiotics, cancer drugs

28
Q

What conditions decrease WBC

A

antiimmune drugs, antibiotics, cancer drugs

29
Q

What causes lymphocytosis

A

viral infections, mumps, measles
autoimmune

30
Q

What can cause lymphopenia?

A

AIDS
corticosteroids
Cushing syndrome