Blood Flashcards
What is the biggest part of blood?
plasma 55%=mostly water
cells= 45%
Where does hematopoiesis happen
red bone marrow= adult has it in sternum and hip
where does warfarin act
activation of factor IX, VII, X, II
1972 Canada vs soviet (Vit K factors)
Where does Apixaban’s act
Xa
Where does the intrinsic and extrinsic pathway connect
factor x activation
Where do heparins act
XA and IIA
Where do dabigatran’s act
activation of factor II
Which factor does LWMH act?
more for XA than IIA
How do antiplatelets work
COX inhibitor
stop aggregation or production
Grel’s, asprin
How do antiplatelets work
COX inhibitor
stop aggregation or production
Grel’s, asprin
What does thrombin do
generates fibrin to give structural integrity
factor IIA
How to get rid of clot
tPA activates plasminogen to lyse clot
What is the classification of anemia
<13g/dl for men
<1.5g/dl
Causes of anemia
bad production- cancer, low amount
destroying- because bad shape
bleed
Causes of anemia
bad production- cancer, low amount
destroying- because bad shape
bleed
What is normocyitc anemia
normal chape but low amount
What is microcytic anemia
shrink= low Iron**
What is macrocytic anemia
big caused by low B12 or folate
Symptoms of anemia
yellow eyes RED IF SEVERE
pale cold, faint, chest pain, angina, low BP, tachycardia
Some causes of low hematopoeisis
low nutrients, bone marrow failure= aplastic anemia
what does intracorpuscular mean and give examples
inside cell so structural deformaties
What does extracorpuscular mean and give examples
caused by not cell, so like antibodies, virus
What is the most common form of anemia
low iron
What does folate do
works with vitamin C and B12 to make RBC and WBC
water sol so no storage
What causes decreased folate
alcohol, overcook veggies, dialysis
What are the WBC disorders
leukocytosis
neutropenia
lymphocytosis
lymphopenia
What conditions increase WBC
infections, inflammation, stress, exercise
What conditions decrease WBC
antiimmune drugs, antibiotics, cancer drugs
What conditions decrease WBC
antiimmune drugs, antibiotics, cancer drugs
What causes lymphocytosis
viral infections, mumps, measles
autoimmune
What can cause lymphopenia?
AIDS
corticosteroids
Cushing syndrome
