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Histology Exam III Material > Liver > Flashcards

Liver Flashcards

1
Q

Space of Mall is continuous with

A

space of Disse

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2
Q

The space of Mall drains into

A

lymphatics

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3
Q

________ covers the surface of the liver except at the diaphragmatic attachment

A

Glisson’s thin capsule of FECT

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4
Q

What are the three types of Hepatic Lobules

A
  • Classic
  • Portal
  • Liver acinus
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5
Q

Structure of Classic Hepatic Lobule

A
  • Central venule is in the center of the lobule

- Portal triads are at the angles

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6
Q

Structure of Portal hepatic lobule

A
  • Three central venules of adjacent lobules form a triangle

- Portions of the bile canaliculi of the three lobules drain into the same bile duct

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7
Q

where are portal triads found

A

at the angles (corners) of classic lobule

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8
Q

What are the three components of the portal triad

A
  • Branch of hepatic artery (arteriole)
  • Branch of portal vein (venule)
  • Bile duct (ductule)
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9
Q

Liver acinus includes ____ zones defined by hepatic tissue receiving blood from a ________________ to opposite ________

A

3, branch of the hepatic artery, to opposite central veins

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10
Q

A characteristic of liver acinus are metabolic gradients that extend from _______ to _____

A

hepatic triad, central vein

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11
Q

Hepatocyte

A
  • Polyhedral in form
  • Central nucleus with one or more nucleoli
  • cytoplasm may contain glycogen, fat droplets, and pigment granules
  • Basolateral domain
    • Microvilli
    • Faces space of Disse
    • involved in
      • absorption of blood-borne substances
      • Secretion of plasma proteins
  • Apical Domain:
    • Borders bile canaliculus
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12
Q

Lining of hepatic sinusoids

A
  • Fenestrated endothelial cells

- Discontinuous basal lamina

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13
Q

Where are perisinusoidal cells found

A

in the space of Disse

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14
Q

Perisinusoidal cells store

A

Vitamin A

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15
Q

Perisinusoidal cells produce

A

collagen fibers and extracellular matrix components

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16
Q

During cirrhosis perisinusoidal cells

A

-Transform into myofibroblasts

  • become the main collagen Type I producing cells
    • Stimulated by cytokines from hepatocytes, Kupffer cells and lymphocytes
17
Q

Subendothelial space of Disse

A
  • Space between basal lamina and hepatocytes
  • contains microvilli of basolateral domain of hepatocytes
  • Contains types I,III, IV collagens
  • Contains interstitial fluid that drains into the space of Mall that drains into lymphatics
18
Q

Kupffer Cells are derived from

A

Monocytes

19
Q

Function of Kupffer Cell

A

Phagocytic cell

20
Q

Kupffer cells line

A

hepatic sinusoids

21
Q

Location of bile canaliculus

A

Extracellular canal located between two rows of hepatocytes

- recieves bile from hepatocytes

22
Q

Function of the Canal of Herining (cholangiole)

A
  • Receives bile from canaliculus

- Carries bile to bile ductule

23
Q

Space of Disse

A
  • Separates hepatic cells from endothelial cells

- Active in transfer between blood and parenchyma

24
Q

Structure of the Gallbladder

A
  • Fundus
  • body
  • neck
    • mucosal folds form the spiral valve of Heister
  • Wall
    • Mucosa
      • Epithelium is tall columnar with a striated border
      • Lamina propria of CT has extensive vascular plexuses and may contain a few smooth cells
      • Rokitansky-Aschoff Sinuses are small diverticula of the mucosa which extend into the muscular and perimuscular layers and may indicate pathological change
    • Muscularis externa
      • Layers of smooth muscle separated by layers of CT
  • Serosa
    • has a broad perimuscular CT coat, rich in blood and lymphatic vessels and elastic fibers
25
Q

Spiral valve of hister

A

Mucosal folds in the neck of the Gallbladder

26
Q

small divertiula of the mucosa of the gallbladder, which extends into the muscular and perimuscular layers and may indicate pathological change

A

Rokitansky-Aschoff

27
Q

major ducts of the gallbladder

A
  • Cystic duct
  • Hepatic duct
  • Common bile duct
28
Q

Mucosa of gallbladder ducts

A

lined with columnar epithelium with goblet cells

29
Q

branches from the portal vein enter the liver lobule and empty into the

A

hepatic sinusoids

30
Q

Afferent blood vessels ive off interlobular branches to the liver name them

A

portal vein

hepatic artery

31
Q

Explain the blood flow from the portal vein and hepatic artery

A

Branches form the portal vein or hepatic artery enter the lobule and empty into hepatic sinusoids which converge toward the center of the lobule and empty into the central vein, central veins unite to form a sublobular vein, tributary of the hepatic vein

32
Q

Functions of the liver

A
  • Removal of bile pigments form the blood and secretion of these pigments into bile
  • Storing of glycogen

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Histology Exam III Material (15 decks)

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