Lipoproteins Flashcards
What are the 5 types of lipoproteins?
Chylomicrons
VLDL -> IDL -> LDL
HDL
Where are chylomicrons formed?
Intestine
What do chylomicrons transport?
They bring dietary TAG from intestines to adipose and other tissues
Where are VLDLs formed?
Liver
What do VLDLs transport?
Transport synthesized TAG from the liver to adipose tissue and to skeletal and heart muscle
Where are IDLs formed?
They are formed via the processing of VLDLs in the circulation
What do IDLs transport?
Delivers remaining TAG and cholesterol to the liver.
Where are LDLs formed?
Formed via processing of IDLs in the circulation
What do LDLs transport?
Delivers cholesterol to the liver and other cells
Where are HDLs formed?
Mainly in the liver with some in the intestine.
What do HDLs transport?
They take cholesterol from peripheral cells and esterify it before transporting it to the liver
What are the other effects of HDLs?
Atheroprotective via enzymes such as paraoxonase that inhibit LDL oxidation
What is the main transport of exogenous lipid?
Chylomicrons
What is the main transport of endogenous lipid?
VLDL/IDL/LDL
What cofactor activates lipoprotein lipase?
Apo-CII
What is the function of lipoprotein lipase?
Hydrolyzes FAs of TAG
What is the cofactor that activates lecithin:cholesterol acyltransferase (LCAT)?
Apo-A1
What is the function of LCAT?
Esterification of cholesterol
What is the remnant receptor ligand that triggers chylomicron function?
Apo E
What is the LDL receptor ligand that triggers LDL receptor mediated protein (LRP) and LDL function?
Apo B-100
What is the HDL receptor ligand that triggers HDL function?
Apo A1
What are the structural proteins of chylomicrons?
B-48
What are the structural protein sod VLDLs?
B-100
What are the structural proteins of HDLs?
A-1
What are HDLs a store for?
Apo A-I
Apo C-II
Apo E
