Lipoproteins

Question 1

What are the 5 types of lipoproteins?

Answer 1

Chylomicrons
VLDL -> IDL -> LDL
HDL

Question 2

Where are chylomicrons formed?

Answer 2

Intestine

Question 3

What do chylomicrons transport?

Answer 3

They bring dietary TAG from intestines to adipose and other tissues

Question 4

Where are VLDLs formed?

Answer 4

Liver

Question 5

What do VLDLs transport?

Answer 5

Transport synthesized TAG from the liver to adipose tissue and to skeletal and heart muscle

Question 6

Where are IDLs formed?

Answer 6

They are formed via the processing of VLDLs in the circulation

Question 7

What do IDLs transport?

Answer 7

Delivers remaining TAG and cholesterol to the liver.

Question 8

Where are LDLs formed?

Answer 8

Formed via processing of IDLs in the circulation

Question 9

What do LDLs transport?

Answer 9

Delivers cholesterol to the liver and other cells

Question 10

Where are HDLs formed?

Answer 10

Mainly in the liver with some in the intestine.

Question 11

What do HDLs transport?

Answer 11

They take cholesterol from peripheral cells and esterify it before transporting it to the liver

Question 12

What are the other effects of HDLs?

Answer 12

Atheroprotective via enzymes such as paraoxonase that inhibit LDL oxidation

Question 13

What is the main transport of exogenous lipid?

Answer 13

Chylomicrons

Question 14

What is the main transport of endogenous lipid?

Answer 14

VLDL/IDL/LDL

Question 15

What cofactor activates lipoprotein lipase?

Answer 15

Apo-CII

Question 16

What is the function of lipoprotein lipase?

Answer 16

Hydrolyzes FAs of TAG

Question 17

What is the cofactor that activates lecithin:cholesterol acyltransferase (LCAT)?

Answer 17

Apo-A1

Question 18

What is the function of LCAT?

Answer 18

Esterification of cholesterol

Question 19

What is the remnant receptor ligand that triggers chylomicron function?

Answer 19

Apo E

Question 20

What is the LDL receptor ligand that triggers LDL receptor mediated protein (LRP) and LDL function?

Answer 20

Apo B-100

Question 21

What is the HDL receptor ligand that triggers HDL function?

Answer 21

Apo A1

Question 22

What are the structural proteins of chylomicrons?

Answer 22

B-48

Question 23

What are the structural protein sod VLDLs?

Answer 23

B-100

Question 24

What are the structural proteins of HDLs?

Answer 24

A-1

Question 25

What are HDLs a store for?

Answer 25

Apo A-I
Apo C-II
Apo E