Lipoproteinemias

Question 0

Plasma appearance of Type I

Answer 0

creamy layer over clear plasma

Question 1

autosomal recessive, usually detected before 10 years of age, TGL levels usually >1000, elevated chylomicrons only

Answer 1

Hyperchylomicronemia /Type I

Question 2

Electrophoretic pattern of Type I

Answer 2

intense band at point of application or at chylomicrons

Question 3

Elevated LDL, normal TGL, increased cholesterol (800-1200mg/dL), 3 variant forms

Answer 3

Hyperbetalipoproteinemia Type IIa

Question 4

Increased beta band on electrophoresis

Answer 4

Hyperbetalipoproteinemia

Question 5

Plasma appearance of Type IIa

Answer 5

Clear/orange

Question 6

common disorder, elevated VLDL, elevated LDL, increased Total chol, increased TGL

Answer 6

Combined Hyperlipoproteinemia/Type IIb

Question 7

Electrophoretic pattern of Type IIb

Answer 7

LARGE beta band

Question 8

Plasma appearance in Type IIb

Answer 8

slightly turbid

Question 9

Lack proper forms of Apo E to allow liver to identify chylomicron remnants and IDL, diagnosed at age 20 or higher, increased total chol and TGL, normal to decreased LDL, increased IDL

Answer 9

Dysbetalipoproteinemia Type III

Question 10

Electrophoretic pattern of Type III

Answer 10

Broad beta band of abnormal composition

Question 11

Plasma appearance of Type III

Answer 11

slightly cloudy to cloudy plasma

Question 12

markedly elevated VLDL, normal LDL, increased TGL, normal chol; deficiency of lipoprotein lipase or Apo CII

Answer 12

Hyperprebetalipoproteinemia Type IV

Question 13

Electrophoretic pattern of Type IV

Answer 13

Increased pre-beta band

Question 14

plasma appearance of Type IV

Answer 14

slightly cloudy, cloudy, or opaque

Question 15

Elevated VLDL and chylomicrons, cholesterol increased, moderately increased TGL, LDL and HDL normal to low

Answer 15

Mixed Hyperlipoproteinemia Type V

Question 16

Plasma appearance of Type V

Answer 16

opaque with floating creamy layer; cottage cheese over milk

Question 17

Electrophoretic pattern of Type V

Answer 17

Type I + Type IV; increased cylomicron band and pre-beta band

Question 18

genetic disorder in which there is a defect in synthesis or secretion of lipoproteins containing Apo-B; LDL is absent in homozygotes; total chol usually <30 mg/dL

Answer 18

abetalipoproteinemia

Question 19

fat absorption problems causing failure to thrive in infancy, mental and physical retardation, blindness, and acanthocytes

Answer 19

abetalipoproteinemia

Question 20

genetic disorder, LDL concentrations about one tenth of normal, total plasma chol may be <30 mg/dL, normal TGL

Answer 20

hypobetalipoproteinemia

Question 21

total chol 40-125 mg/dL, normal to elevated TGL, familial severe HDL and Apo A-I deficiency, hyperplastic orange-yellow tonsils and adenoids plus hepatosplenomegaly

Answer 21

Hypoalphalipoproteinemia (Tangier Disease)

Question 22

elevated TGL without significantly increased Chol would cause increases in which two lipoproteins?

Answer 22

VLDL and Chylomicrons

Question 23

Elevated Chol without increased TGL may be due to increases in which three lipoprotein fractions?

Answer 23

LDL, IDL, and HDL