Lipoprotein (BIOCHEM) Flashcards
1
Q
Proteins that act to transport lipids
A
Lipoproteins
2
Q
main transport of lipoprotein
A
transport Triglycerides and Cholestero
3
Q
Largest and least dense
A
Chylomicrons
4
Q
APO-B 48
A
chylomicrons
5
Q
Positive result: Floating Creamy Layer
A
Chylomicrons
6
Q
Also known as Pre-Beta Lipoprotein
A
VLDL
7
Q
Transports Endogenous triglycerides
A
VLDL
8
Q
Apo-B 100
A
VLDL
9
Q
Positive result: Turbid
A
VLDL
10
Q
Smallest lipoproteins but the most dense
A
HDL
11
Q
reference method for protein determination
A
kjeldahl
12
Q
violet colored complex
A
biuret
13
Q
most specific, preciss
A
Bromcresol Purple
14
Q
most commonly used dye
A
Bromcresol Green
15
Q
beta gamma bridging
A
Hepatic cirrhosis
16
Q
Gamma Spike/ Monoclonal spike
A
Multiple myeloma
17
Q
increased A2, Decreased A1
A
Nephrotic Syndrome
18
Q
Decrease A1 antotrypsin
A
empysema
19
Q
increased A1, A2, Beta
A
inflammation
20
Q
hereditary absence of Albumin
A
Analbuminemia
21
Q
presence of two albumin bonds
A
Bisalbumin
22
Q
CA 125
A
Ovarian cancer
23
Q
CA 15-3
A
Breast Cancer
24
Q
CA 19-9
A
Pancreatic Cancer
25
CA 72-4
Gastric Cancer
26
Transports Exogenous triglycerides
Chylomicrons
27
Primary marker for Coronary Heart Disease
LDL
28
Primary marker for Coronary Heart Disease
LDL
29
Product of VLDL catabolism or remnant of VLDL
IDL
30
Known as the sinking pre-B Lipoprotein
Lp-A
31
Floating B Lipoprotein
B-VLDL
32
Found in obstructive jaundice and LCAT deficiency
Lp-X
33
Reference method for quantitation of lipoproteins
Ultracentrifugation
34
what are the two formulas
friedwald's formula and delong's formula
35
friedwald formula
TAG/5.0 (mg/dl)
36
what type does hyperchylomicronemia
type 1
37
what type does hypercholesterolemia
type 2a
38
what type does hyperlipidemia
type 2b
39
what type does dysbetalipoproteinemia
type 3
40
what type does hypertriglyceridemia
type 4
41
what type does hyperlipidemia
type 5
42
what type is extremely elevated due to chylomicrons
type 1
43
what type is elevated ldl
type 2a
44
what type is the elevated presence of idl
type 3
45
what type is the elevated tag due to VLDL
type 4
46
complete absence of HDL
Tangier's disease
47
defective apo B synthesis and absence of VLDL, LDL and chylomicrons
Bassen-Kornzwieg
48
Hunter and Hurler disease
Mucopolysaccharide disease
49
Polymers of amino acids joined together by
peptide bond
50
the only element that distinguishes protein from other biomolecules
Nitrogen
51
Most abundant macromolecules in the body
Protein
52
building blocks of protein
Amino acids
53
simple amino acid
Glycine
54
hinge region
proline
55
start codon
methionine
56
stop codon
UAG, UAA, UGA
57
Indicator of malnutrition, binds thyroid hormones and retinol-binding protein
Pre-albumin
58
Binds bilirubin, steroids, fatty acids, major contributor to oncotic pressure
albumin
59
protease inhibitor
a-1 antitrypsin
60
principal fetal protein
a-1 fetoprotein
61
may be related to immune response
a-1 acid glycoprotein
62
binds free hemoglobin
haptoglobin
63
transport copper, peroxidase activity
ceruloplasmin
64
inhibits thrombin, trypsin and pepsin
a-2 macroglobulin
65
transport iron
transferin
66
binds heme
hemopexin
67
for immune response by promoting cell lysis
complement
68
precursor of fibrin
fibrinogen
69
for inflammation and opsonin
c-reactive proteins
70
protein found on CSF
Tau protein
71
Transporter of T4 and Retinol
pre albumin
72
highest concentration in plasma
albumin
73
it is a negative acute phase reactant
albumin
74
Lowest plasma Albumin can be seen in
Nephrotic Syndrome
75
increased albumin indicates
dehydration
76
major protease inhibitor
alpha-1 antitrypsin
77
Neutralizes trypsin- like enzymes but can destroy the alveoli leading to
emphysema
78
major component of a-1 globulin band
antitrypsin
79
Initially synthesized by fetal yolk sac and fetal liver
fetoprotein
80
Increased in: neural tube defects like Spina bifida, presence of twins
fetoprotein
81
Also known as Orosomucoid
acid glycoprotein
82
Greatest affinity to progesterone
acid glycoprotein
83
Major transporter of PSA or Prostate Specific Antigen
chymotrypsin
84
increased in alzheimer's disease
chymotrypsin
85
increased in nephrotic syndrome
macroglobulin
86
2nd biggest protein next to albumin
macroglobulin
87
copper binding protein
ceruloplasmin
88
Decreased in Wilson`s disease and Menkes kinky-hair syndrome
ceruloplasmin
89
negative phase acute reactant
transferrin
90
Major component of the beta globulin fraction
tranferrin
91
Component of the major Human Leukocyte Antigen (MHC I)
microglubin
92
most abundant factor in coagulation
fibrinogen
93
lysis of foreign agents
complement
94
most abundant form in serum
C3
95
major acute phase reactant
reactive protein
96
immunoglobulins are synthesized by
plasma cells
97
most abundant, can cross the placenta
IgG
98
found in secretions
IgA
99
first antibody to appear
IgM
100
present on surface of B cells
IgD
101
allergic, anaphylactic and parasitic infection
IgE
102
nitrogen content of protein is
16%
103
most widely or routine used
biuret
104
most abundant of the coagulation factors which forms the fibrin clot.
fibrinogen
105
Fibrinogen is precipitated with calcium
howe's method
106
Fibrinogen is precipitated with ammonium sulfate and sodium chloride
Parfentjev method
107
stains of protein electrophoresis
coomassie blue, amindo black, ponceau S
108
Carcinoembryonic antigen (CEA)
Colon Cancer
109
Alpha- fetoprotein
liver cancer
110
Prostate Specific Antigen
prostate cancer
111
acid phosphatase
prostate cancer
112
Beta-Human Chorionic Gonadotropin (B-HCG)
Men- testicular cancer
Female- choriocarcinoma
113
calcitonin
medullary thyroid cancer
114
Her-2/Neu
Breast Cancer
115
NMP 22
Urinary Bladder Cancer
116
Bence Jones Proteins
Multiple Myeloma
