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2nd year, 1st sem > Lipoprotein (BIOCHEM) > Flashcards

Lipoprotein (BIOCHEM) Flashcards

1
Q

Proteins that act to transport lipids

A

Lipoproteins

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2
Q

main transport of lipoprotein

A

transport Triglycerides and Cholestero

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3
Q

Largest and least dense

A

Chylomicrons

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4
Q

APO-B 48

A

chylomicrons

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5
Q

Positive result: Floating Creamy Layer

A

Chylomicrons

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6
Q

Also known as Pre-Beta Lipoprotein

A

VLDL

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7
Q

Transports Endogenous triglycerides

A

VLDL

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8
Q

Apo-B 100

A

VLDL

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9
Q

Positive result: Turbid

A

VLDL

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10
Q

Smallest lipoproteins but the most dense

A

HDL

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11
Q

reference method for protein determination

A

kjeldahl

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12
Q

violet colored complex

A

biuret

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13
Q

most specific, preciss

A

Bromcresol Purple

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14
Q

most commonly used dye

A

Bromcresol Green

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15
Q

beta gamma bridging

A

Hepatic cirrhosis

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16
Q

Gamma Spike/ Monoclonal spike

A

Multiple myeloma

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17
Q

increased A2, Decreased A1

A

Nephrotic Syndrome

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18
Q

Decrease A1 antotrypsin

A

empysema

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19
Q

increased A1, A2, Beta

A

inflammation

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20
Q

hereditary absence of Albumin

A

Analbuminemia

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21
Q

presence of two albumin bonds

A

Bisalbumin

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22
Q

CA 125

A

Ovarian cancer

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23
Q

CA 15-3

A

Breast Cancer

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24
Q

CA 19-9

A

Pancreatic Cancer

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25
Q

CA 72-4

A

Gastric Cancer

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26
Q

Transports Exogenous triglycerides

A

Chylomicrons

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27
Q

Primary marker for Coronary Heart Disease

A

LDL

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28
Q

Primary marker for Coronary Heart Disease

A

LDL

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29
Q

Product of VLDL catabolism or remnant of VLDL

A

IDL

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30
Q

Known as the sinking pre-B Lipoprotein

A

Lp-A

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31
Q

Floating B Lipoprotein

A

B-VLDL

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32
Q

Found in obstructive jaundice and LCAT deficiency

A

Lp-X

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33
Q

Reference method for quantitation of lipoproteins

A

Ultracentrifugation

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34
Q

what are the two formulas

A

friedwald’s formula and delong’s formula

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35
Q

friedwald formula

A

TAG/5.0 (mg/dl)

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36
Q

what type does hyperchylomicronemia

A

type 1

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37
Q

what type does hypercholesterolemia

A

type 2a

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38
Q

what type does hyperlipidemia

A

type 2b

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39
Q

what type does dysbetalipoproteinemia

A

type 3

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40
Q

what type does hypertriglyceridemia

A

type 4

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41
Q

what type does hyperlipidemia

A

type 5

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42
Q

what type is extremely elevated due to chylomicrons

A

type 1

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43
Q

what type is elevated ldl

A

type 2a

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44
Q

what type is the elevated presence of idl

A

type 3

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45
Q

what type is the elevated tag due to VLDL

A

type 4

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46
Q

complete absence of HDL

A

Tangier’s disease

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47
Q

defective apo B synthesis and absence of VLDL, LDL and chylomicrons

A

Bassen-Kornzwieg

48
Q

Hunter and Hurler disease

A

Mucopolysaccharide disease

49
Q

Polymers of amino acids joined together by

A

peptide bond

50
Q

the only element that distinguishes protein from other biomolecules

A

Nitrogen

51
Q

Most abundant macromolecules in the body

A

Protein

52
Q

building blocks of protein

A

Amino acids

53
Q

simple amino acid

A

Glycine

54
Q

hinge region

A

proline

55
Q

start codon

A

methionine

56
Q

stop codon

A

UAG, UAA, UGA

57
Q

Indicator of malnutrition, binds thyroid hormones and retinol-binding protein

A

Pre-albumin

58
Q

Binds bilirubin, steroids, fatty acids, major contributor to oncotic pressure

A

albumin

59
Q

protease inhibitor

A

a-1 antitrypsin

60
Q

principal fetal protein

A

a-1 fetoprotein

61
Q

may be related to immune response

A

a-1 acid glycoprotein

62
Q

binds free hemoglobin

A

haptoglobin

63
Q

transport copper, peroxidase activity

A

ceruloplasmin

64
Q

inhibits thrombin, trypsin and pepsin

A

a-2 macroglobulin

65
Q

transport iron

A

transferin

66
Q

binds heme

A

hemopexin

67
Q

for immune response by promoting cell lysis

A

complement

68
Q

precursor of fibrin

A

fibrinogen

69
Q

for inflammation and opsonin

A

c-reactive proteins

70
Q

protein found on CSF

A

Tau protein

71
Q

Transporter of T4 and Retinol

A

pre albumin

72
Q

highest concentration in plasma

A

albumin

73
Q

it is a negative acute phase reactant

A

albumin

74
Q

Lowest plasma Albumin can be seen in

A

Nephrotic Syndrome

75
Q

increased albumin indicates

A

dehydration

76
Q

major protease inhibitor

A

alpha-1 antitrypsin

77
Q

Neutralizes trypsin- like enzymes but can destroy the alveoli leading to

A

emphysema

78
Q

major component of a-1 globulin band

A

antitrypsin

79
Q

Initially synthesized by fetal yolk sac and fetal liver

A

fetoprotein

80
Q

Increased in: neural tube defects like Spina bifida, presence of twins

A

fetoprotein

81
Q

Also known as Orosomucoid

A

acid glycoprotein

82
Q

Greatest affinity to progesterone

A

acid glycoprotein

83
Q

Major transporter of PSA or Prostate Specific Antigen

A

chymotrypsin

84
Q

increased in alzheimer’s disease

A

chymotrypsin

85
Q

increased in nephrotic syndrome

A

macroglobulin

86
Q

2nd biggest protein next to albumin

A

macroglobulin

87
Q

copper binding protein

A

ceruloplasmin

88
Q

Decreased in Wilson`s disease and Menkes kinky-hair syndrome

A

ceruloplasmin

89
Q

negative phase acute reactant

A

transferrin

90
Q

Major component of the beta globulin fraction

A

tranferrin

91
Q

Component of the major Human Leukocyte Antigen (MHC I)

A

microglubin

92
Q

most abundant factor in coagulation

A

fibrinogen

93
Q

lysis of foreign agents

A

complement

94
Q

most abundant form in serum

A

C3

95
Q

major acute phase reactant

A

reactive protein

96
Q

immunoglobulins are synthesized by

A

plasma cells

97
Q

most abundant, can cross the placenta

A

IgG

98
Q

found in secretions

A

IgA

99
Q

first antibody to appear

A

IgM

100
Q

present on surface of B cells

A

IgD

101
Q

allergic, anaphylactic and parasitic infection

A

IgE

102
Q

nitrogen content of protein is

A

16%

103
Q

most widely or routine used

A

biuret

104
Q

most abundant of the coagulation factors which forms the fibrin clot.

A

fibrinogen

105
Q

Fibrinogen is precipitated with calcium

A

howe’s method

106
Q

Fibrinogen is precipitated with ammonium sulfate and sodium chloride

A

Parfentjev method

107
Q

stains of protein electrophoresis

A

coomassie blue, amindo black, ponceau S

108
Q

Carcinoembryonic antigen (CEA)

A

Colon Cancer

109
Q

Alpha- fetoprotein

A

liver cancer

110
Q

Prostate Specific Antigen

A

prostate cancer

111
Q

acid phosphatase

A

prostate cancer

112
Q

Beta-Human Chorionic Gonadotropin (B-HCG)

A

Men- testicular cancer
Female- choriocarcinoma

113
Q

calcitonin

A

medullary thyroid cancer

114
Q

Her-2/Neu

A

Breast Cancer

115
Q

NMP 22

A

Urinary Bladder Cancer

116
Q

Bence Jones Proteins

A

Multiple Myeloma

2nd year, 1st sem (41 decks)

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