Lipid Metabolism

Question 1

Humans and other mammals prefers to store excess energy only in the form of lipid because?

Answer 1

• Energy content of lipid is 2-3times higher.
• Lipid can be stored without water of hydration.
• Oxidation of lipids produces more water.

Question 2

True or false? lipids can meet energy requirement for a week.

Answer 2

True

Question 3

How do camels suit well to dry conditions

Answer 3

It derives water and energy from large amount of lipids.

Question 4

Defect or changes in tgepathways of lipid metabolism are directly related to development of diseases.

Answer 4

True

Question 5

Increased fatty acid oxidation in starvation and diabetes leads to

Answer 5

Keto acidosis

Question 6

Decreased fatty acid oxidation leads to

Answer 6

Hypoglycemia

Question 7

Aspirin; an inflammatory drug works by

Answer 7

inhibiting prostagladin formation.

Question 8

Hypoglycin causes

Answer 8

Hypoglycemia

Question 9

Excessive fat accumulation leads to

Answer 9

Obesity

Question 10

Bile salt produced by cholesterol is required for

Answer 10

Absorption of dietary lipids.

Question 11

Inhibitors of bile acid formation are used in the treatment of

Answer 11

Atherosclerosis

Question 12

Among lipids, Stored form of energy is

Answer 12

Triglycerides

Question 13

During fasting or in between meals triglycerides are broken down into

Answer 13

glycerol and fatty acids.

Question 14

List some biochemical activities that take place in the mitochondrial

Answer 14

Lipid metabolism, kreb’s cycle, Oxidative Phosphorylation. part of urea cycle too.

Question 15

Carnitine is protein in the outer membrane of the mitochondrial that helps in the………..,..

Answer 15

Movement of long chain fatty acids into the cell.

Question 16

Long chain fatty acids oxidation involve?

Answer 16

Activation in outer mitochondrian, membrane.

Transport of activated fatty acids across inner membrane.

Oxidation in the mitochondrial.

Question 17

…… In the outer mitochondrial membrane is responsible for activation of long fatty acids.

Answer 17

Acyl COA Synthases(thiokinase)

Question 18

Long chain fatty acids oxidation involves

Answer 18

Activation in outer membrane

Transport of activated fatty acids across inner mitochondrial membrane.

Oxidation in mitochondrial.

Question 19

Canitineacyl transferase I regulates entry of ………into ……..

Answer 19

Fatty acids into mitochondrial.

Question 20

Acyl carnitine is translocated to the matrix of mitochondrial by

Answer 20

Carnitine acylcarnitine translocase(in the inner membrane).

Question 21

What is tge fundtion of CAT II

Answer 21

Liberates acyl group from acyl carnitine as acyl - COA.

Question 22

To complete carnitine shuttle, carnitine is sent back to outer of inner mitochondrial membrane by

Answer 22

Carnitine acyl-carnitine translocase.

Question 23

B- oxidation is………….

Answer 23

Degradation of fatty acids or acyl CoA Sequential removal of 2 carbon atoms at a true form the carbonyl end after the B carbon has been converted to ketoform

Question 24

Degradation of Acyl CoA to acetyl CoA

Answer 24

Beta Oxidation

Question 25

How many reactions are involved in the beta oxidation of acyl CoA

Answer 25

Four reactions

Question 26

The first three reactions of Beta oxidation is to convert beta carbon to what form?

Answer 26

B- keto acyl CoA

Question 27

The B- Keto acyl CoA is split into

Answer 27

Acetyl CoA and an acyl-CoA(which is smaller by 2carbons)

Question 28

The acyl CoA smaller by two carbons undergo B-oxidation once again. True or false

Answer 28

True till acyl CoA is completely converted to acetyl CoA

Question 29

The reaction sequence of B-Oxidation includes

Answer 29

Dehydrogenation of acyl-CoA

Addition of Water across the double bond (by Enoyl- CoA hydratase)

Dehydrogenation of B-hydroxy acyl-CoA to B- Keto acyl-CoA.

Lytic reaction of B-Keto acyl -CoA to give one acetyl- CoA and an acyl-CoA(2 carbon less)

Question 30

Among lipids, …….serve as stored form of energy and are broken down to……….., and ……….

Answer 30

a) triglycerides

b) fatty acids and glycerol.

Question 31

95% of energy from lipids are from

Answer 31

Fatty acids

Question 32

At the plasma membrane fatty acid dissociates from …………. and combines with membrane , fatty acid binding protein , which transports fatty acid into ………….. along with ……….

Answer 32

Albumin,cytosol , Sodium ion(Na+)

Question 33

True/False

In the mitochondria there exists distinct acyl-CoA dehydrogenase for short, medium and long chain acyl-CoAs

Answer 33

True

Question 34

The catalyst in the dehydrogenation of acyl CoA is

Answer 34

FAD containing acyl-CoA dehydrogenase.

Question 35

The product of the first dehydrogenation reaction of acyl-CoA is ……….

Answer 35

∆^2 trans- enoyl- CoA.

Question 36

What is the fate of FAD in the the dehydrogenase reaction of acyl-CoA

Answer 36

FAD is converted to FADH2

Question 37

In B oxidation of acyl-CoA Addition of water across the double bond is by …….

Answer 37

Enoyl CoA Hydra tase.( which is stereo specific.

Question 38

The NAD dependent reaction I’in the B oxidation of acyl CoA &other long chain fatty acids is?

Answer 38

In the dehydrogenation of B- hydroxyl acyl CoA to B- keto acyl CoA

Question 39

The end products of dehydrogenation of B- hydroxl Acyl-CoA gives

Answer 39

B- Keto acyl CoA

Question 40

..,.. Causes the splitting of –C—C bond of keto acyl -CoA

Answer 40

B-keto acyl- CoA thiolase and the splitting occurs at the a &B(alpha &Beta carbon atoms

Question 41

The product if the beta oxidation of stearic acid gives ……..as profucys

Answer 41

9acetyl COA, 8FADHz and 8NADH

Question 42

Propionate is gotten from?

Answer 42

Odd number fatty acid metabolism. It is mainly produced in the rumen of ruminants by bacteria.

Question 43

In humans propionyl CoA may arises from

Answer 43

Beta propionyl- CoA

Question 44

Propionate and and propionyl-CoA are converted to

Answer 44

Glucose