LG 2.3 Electrophysiology of Neurons Flashcards
What are EPSP?
- Excitatory post synaptic potential
- Synaptic inputs that depolarize the postsynaptic cell.
What channels are normally involved with EPSP?
Produced by opening potassium and sodium channels
What neurotransmitters are normally involved with EPSP?
-Ach, norepinephrine, epinephrine, dopamine, glutamate, and serotonin
What are IPSP?
- Inhibitory post synaptic potential
* Hyperpolarize cell membrane
What channels are normally involved with IPSP?
- Opening of Cl- channels
What neurotransmitters are normally involved with IPSP?
GABA and Glycine
What are the types of synaptic arrangements (number) ?
- One-to-one (neuromuscular junction)
- One-to-many
- Many-to-one
What are the types of synaptic arrangements (location)?
- Presynaptic Inhibition
- Axosomatic synapses
- Axodendritic synapses
What is the main excitatory neurotransmitter?
Glutamate
What types of receptors does Glutamate have?
Four subtypes of receptors
•3 are Ionotropic
-AMPA, NMDA
•Metabotropic
What reuptakes glutamate?
Glia cells
What are defining features of seratonin receptors?
- Direct gating of cation channel (5-HT3, excitatory)
* G-protein coupled effects on K+ channel (5-HT1-2, 4-7, excitatory and inhibitory
What is the Length Constant?
- Decay over distance
* Membrane resistance and internal (longitudinal resistance)
What is long term potential?
It is a persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse. Studies of LTP are often carried out in slices of the hippocampus, an important organ for learning and memory.
What is long-term depression?
It is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.
