LG 1.13 Early Development of the Nervous System Flashcards

1
Q

What happens at day 16-18?

A

Formation of neural plate

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2
Q

What happens at day 19-20?

A

Neural folds elevate

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3
Q

What happens at day 21-24?

A

Fusion of neural folds

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4
Q

What happens at day 25?

A

Cranial neuropore closes

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5
Q

What happens at day 27?

A

caudal neuropore closes

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6
Q

How does the ventricular system develop?

A

From the single cavity formed from the hollow neural tube

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7
Q

When is embryonic CSF formed?

A

Week 5

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8
Q

What does the neural tube give rise to (general)?

A

CNS

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9
Q

What happens during gastrulation?

A

Converts the bilaminar embryo to a trilaminar embryo

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10
Q

Where does the notochord form?

A

On the midline of the mesoderm

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11
Q

What does the notochord induce growth of?

A

Neural plate

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12
Q

What is Neurulation?

A

Folding of neural plate in to a closed tube of ectoderm

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13
Q

What results from failure to close anterior neuropore?

A
  • Anencephaly

- Failure to develop brain, cranial vault

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14
Q

What is spina bifida?

A
  • Results from incomplete closer of the embryonic neural tube.
  • Usually sacrolumbar
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15
Q

What are the types of Spina bifida?

A
  • Meningocele: protrusion of meninges
  • Meningomyelocele: protrusion of meninges and spinal cord
  • Rachischisis: open neural tube
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16
Q

What is one method of preventing neural tube defects?

A

Folic acid

17
Q

When does Segmentation of the CNS happen?

A

4th week, 3 primary brain vesicles are formed

18
Q

When does myelination begin?

A

3rd trimester and continues after birth

19
Q

When does the most brain growth occur?

A

After birth

20
Q

What does the prosencephalon give rise to?

A
  • Telencephalon

- Diencephalon

21
Q

What does the mesencephalon give rise to?

A

Mesencephalon

22
Q

What does the Rhombencephalon give rise to?

A

Metencephalon and mylencephalon

23
Q

What does the telencephalon become?

A

Cerebral hemispheres

24
Q

What does the diencephalon become?

A

Thalamus and hypothalamus

25
What does the mesencephalon become?
midbrain
26
What does the met encephalon become?
pons and cerebellum
27
What does the mylencephalon become?
medulla
28
What does the myelon become?
spinal cord
29
What 3 layers does the neural tube form?
1) Ventricular Layer 2) Mantle Layer (Gray matter) 3) Marginal Layer (white matter)
30
What arises from the neural crest?
* Cranial and sensory ganglia and nerves * Medulla of suprarenal gland * Pigment cells * Pharyngeal arch cartilages * Head mesenchyme and connective tissue * Bulbar and truncal ridges in heart
31
What is Hirschsprung's disease?
- results from a failure of neural crest migration - congenital aganglionic megacolon - newborn has constipation without physical obstruction - absence of ganglia in lower colon - caused by mutation in several genes