2.15 Pharmacology of Stroke Medications

Question 1

What is MOA of warfarin?

Answer 1

Warfarin: Inhibits liver production of vitamin K dependent clotting factors: II, VII, IX, X

Question 2

What is the MOA of Dabigatran?

Answer 2

direct thrombin inhibitor

Question 3

What is the MOA of Rivaroxaban and Apixaban?

Answer 3

Factor Xa inhibitors

Question 4

What are fibrinolytic drugs?

Answer 4

• Alteplase
• Reteplase
• Urokinase
• Tenecteplase
• (historical) Streptokinase

Question 5

What is the MOA of Fibrinolytics?

Answer 5

a

Question 6

What is the only agent class approved for stroke treatment?

Answer 6

Alteplase (r-tPA): Only agent in class approved for stroke treatment; stroke dosing- IV bolus then 60 min infusion

Question 7

What are uses of Fibrinolytics?

Answer 7

-Catheter occlusions,
-DVT
-MI
Peripheral arterial occlusions
-Pulmonary embolism
-Stroke

Question 8

What major adverse effect of fibrinolytic therapy?

Answer 8

Intracranial hemorrhage

Question 9

What is the MOA of Aspirin?

Answer 9

• Inhibit Aggregation

- Block cyclo-oxygenase (COX-1)

Question 10

What is the MOA of Clopidogrel, prasugrel, ticagrelor, and ticlopidine?

Answer 10

• Inhibit Aggregation

- Block ADP receptor (P2Y12)

Question 11

What is the MOA of Abciximab, tirofiban, and eptifibitide?

Answer 11

• Inhibit aggregation

- Block IIb-IIIa receptor

Question 12

What is the MOA of Vorapaxar?

Answer 12

• Inhibit aggregation

- Block thrombin receptor (PAR-1)

Question 13

What is the MOA of dipyridamole?

Answer 13

• Inhibit aggregation

- Increase adenosine levels

Question 14

What is the checklist used for?

Answer 14

Cognitive Aid