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NMSK B Test 1 > 1.8 Neurotransmitter Biochemistry: Acetylcholine and Serotonin (pg 291-306) > Flashcards

1.8 Neurotransmitter Biochemistry: Acetylcholine and Serotonin (pg 291-306) Flashcards

1
Q

What is the ionic receptor for Ach?

A

Cholinergic nicotinic

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2
Q

What is the metabotropic receptor for Ach?

A

Cholinergic muscarinic

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3
Q

What makes the Cholinergic nicotinic receptor different?

A

Are ion channels that contain five protein subunits that bind more tightly to nicotine than to muscarine

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4
Q

What makes the Cholinergic muscarinic different?

A

G-protein coupled receptors that contain a single protein that binds more tightly to muscarine than to nicotine

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5
Q

What is an Acetyl group?

A

Two carbon chemical group, attached through an ester bond

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6
Q

What is a Choline?

A

An amine containing compound that is often found in the liver

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7
Q

Where is Ach produced?

A

o Diagonal band of Broca, Medial septal nucleus, nucleus basalis, and pedunculopontine nucleus.

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8
Q

In the brain what is Ach responsible for?

A

Attention, memory

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9
Q

What actions is dopamine in charge of in the brain?

A

Reward, attention, decisions

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10
Q

Where is dopamine made?

A

Substantia nirgra

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11
Q

What is actions is serotonin mainly in charge of?

A

Homeostatis, sleep, wake, pain

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12
Q

What does serotonin do in the endothelial cells?

A

Regulates blood pressure

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13
Q

What does serotonin do in the intestines?

A

Regulates digestion

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14
Q

What molecule is serotonin derived from?

A

Tryptophan

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15
Q

What converts tryptophan to 5-hydroxytrptophan?

A

Tryptophan hydroxylase

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16
Q

What is another name for serotonin?

A

5-hydroxytrptophan

17
Q

What does Tryptophan hydroxylase, phenylalanine hydroxylase, and tyrosine hydroxyls require for activation?

A

-molecular oxygen (O2) by iron and tetrahydrobiopterin

cofactors

18
Q

What actions does Norepinephrine have in the brain?

A

Attention, response to stimuli

19
Q

What does molecularly does acetylchonline esterase do?

A

Hydrolysis of an ester bond inserts the oxygen atom from the water to form a carboxylic

20
Q

What is norepinephrine made?

A

Locus ceruleus, laterel tegmental system

21
Q

What does choline acetytransferase do?

A

Binds to choline and to acetylcoenzyme A and transferse the actyl group from acetylcoenzyme-A to choline

22
Q

What does a deficiency of choline cause?

A

Deficiency of choline interferes with lipid processing and leads to fat buildup in the liver (Nonalcoholic fatty liver disease = NAFLD)

NMSK B Test 1 (27 decks)

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