Leukemias

Question 1

The primary chemotherapeutic drug for acute lymphocytic leukemia and it’s catastrophic side effect.

Answer 1

Asparginase (pancreatitis)

Question 2

Vehicle used for the delivery of chemotherapy to CNS sanctuary sites of ALL

Answer 2

Ommaya reservoir

Question 3

t(12;21)

Answer 3

ALL

Question 4

Hypercellular marrow packed with myeloblasts, >20% myloblasts in BM, MPO-positive

Answer 4

AML

Question 5

t(15;17)

Answer 5

Acute Promyelocytic Leukemia

Question 6

Leukemia with highest incidence of DIC

Answer 6

Acute Promyelocytic Leukemia

Question 7

Only human cancer that can be treated with vitamins

Answer 7

Acute Promyelocytic leukemia (all-trans retinoic acid)

Question 8

The primary chemotherapeutic drug for CML and it’s side effects

Answer 8

Imatinib(Gleevec), fluid retention, CHF

Question 9

Most common leukemia of adults and the elderly

Answer 9

Chronic lymphocytic leukemia

Question 10

Complication of CLL, transformation into diffuse large B-cell lymphoma

Answer 10

Richter syndrome (aggressive type of Non-Hodgkins Lymphoma)

Question 11

Increase in WBC count with left shift (eg. 80% bands) and high alkaline phosphatase usually caused by infection.

Answer 11

Leukemoid reaction

Question 12

Differentiates leukemoid reaction from CML

Answer 12

Leukemoid-high leukocyte alkaline phosphatase

CML-very low leukocyte alkaline phosphatase

Question 13

Large cells with multiple nuclei or a single nucleus with multiple nuclear lobes seen in Hodgkin’s Lymphoma.

Answer 13

Reed-Sternbherg cells (Owl’s eyes)

Question 14

Most common type of Hodgkin’s lymphoma

Answer 14

Nodular sclerosis (65-75%)

Question 15

Type of Hodgkin’s lymphoma with worst prognosis

Answer 15

Lymphocyte depleted (rare, 90% assoc. with EBV)

Question 16

Treatment of choice for relapse Hodgkin’s Lymphoma after initial treatment

Answer 16

Bone marrow transplant

Question 17

Most common hematopoietic malignancy

Answer 17

Non-Hodgkin’s lymphoma

Question 18

Most commonly form of indolent NHL

Answer 18

Follicular lymphoma

Question 19

t(14;18)

Answer 19

Follicular lymphoma

Question 20

Most common form of NHL

Answer 20

Diffuse Large B-cell Lymphoma

Question 21

t(8;14)

Answer 21

Burkitt’s lymphoma

Question 22

Sezary-Lutzner cells, Pautrier microabscesses

Answer 22

Cutaneous T-Cell Lymphoma

Question 23

Most common and most deadly plasma cell neoplasm

Answer 23

Multiple Myeloma

Question 24

Most important gammopathu

Answer 24

Multiple myeloma

Question 25

Differentiates Waldenstorm’s Macroglobulinemia from Multiple Myeloma

Answer 25

Absence of lytic bone lesions

Question 26

Neutrophils with only two nuclear lobes

Answer 26

Pseudo-Pelger-Hüet Cells

Question 27

Hallmark is development of obliterative marrow fibrosis

Answer 27

Primary myelofibrosis

Question 28

Treatment of primary myelofibrosis

Answer 28

Bone marrow transplant

Question 29

Birbeck granules

Answer 29

Langerhans cell histiocytosis

Question 30

Proliferative disorder of dendritic cells

Answer 30

Langerhans cell histiocytosis

Question 31

Leading cause of irreversible blindness in the developed world

Answer 31

Age-related macular degeneration

Question 32

Most common primary intra-ocular malignancy of children

Answer 32

Retinoblastoma

Question 33

Most common presentation of retinoblastoma

Answer 33

Leukocoria

Question 34

Most important cause of optic neuritis

Answer 34

Multiple sclerosis

Question 35

Most common cancer of children

Answer 35

Acute lymphoblastic leukemia