Inflammation Flashcards
Characteristic of Exudate
Cellular
Protein rich
SG >1.012
Usually seen in infections
Initial vascular event in acute inflammation
Transient vasoconstriction
First step leukocyte extravasation
- Margination
- Rolling
- Tight binding
- Diapedesis
- Migration/chemotaxis
Inflammatory mediators of vasodilation
Histamine, NO, Prostaglandin
Chemical inflammatory mediator of fever
IL-1
TNF
Prostaglandin
Chemical inflammatory mediator of pain
Prostaglandin, bradykinin
Conditions with decrease ESR
Sickle cell anemia
Polycythemia
CHF
Biochemical disorder in heme synthesis presents with skin blistere d/t photosensitivity
Porphyria
Most common: Porphyria cutanea tarda - deficient URO decarboxylase
Most common complication of PUD
- bleeding
- Perforation
- Obstruction
Antibiotics regarded as common cause of pseudomembranous colitis
Clindamycin
2nd 3rd gen cephalosporin
Ampicillin
Treatment for antibiotic related pseudomembranous colitis
Stop offending antibiotic
Give metronidazole/vancomycin
Cytokine of chronic inflammation that activates macrohages
IFN-y (from T lymphocytes, NK cells)
Cytokine of chronic inflammation for neutrophil and monocyte recruitment
IL-17 (T lymphocytes)
Cytokine produced in chronic inflammation that induces IFN-y production
IL-12
Response to inflammation. Cellular attempt to contain an offending agent that is difficult to eradicate
Granuloma formation
DMARD that may cause reactivation of latent TB
infliximab (do precautionary PPD)
Cat scratch disease
Bartonella henselae
Noninfectious cause of granulomatous inflammation
Sarcoidosis
Crohn’s disease
Beryllioisis
Hallmark of acute inflammation
Increased vascular permeability
