Inflammation Flashcards
Characteristic of Exudate
Cellular
Protein rich
SG >1.012
Usually seen in infections
Initial vascular event in acute inflammation
Transient vasoconstriction
First step leukocyte extravasation
- Margination
- Rolling
- Tight binding
- Diapedesis
- Migration/chemotaxis
Inflammatory mediators of vasodilation
Histamine, NO, Prostaglandin
Chemical inflammatory mediator of fever
IL-1
TNF
Prostaglandin
Chemical inflammatory mediator of pain
Prostaglandin, bradykinin
Conditions with decrease ESR
Sickle cell anemia
Polycythemia
CHF
Biochemical disorder in heme synthesis presents with skin blistere d/t photosensitivity
Porphyria
Most common: Porphyria cutanea tarda - deficient URO decarboxylase
Most common complication of PUD
- bleeding
- Perforation
- Obstruction
Antibiotics regarded as common cause of pseudomembranous colitis
Clindamycin
2nd 3rd gen cephalosporin
Ampicillin
Treatment for antibiotic related pseudomembranous colitis
Stop offending antibiotic
Give metronidazole/vancomycin
Cytokine of chronic inflammation that activates macrohages
IFN-y (from T lymphocytes, NK cells)
Cytokine of chronic inflammation for neutrophil and monocyte recruitment
IL-17 (T lymphocytes)
Cytokine produced in chronic inflammation that induces IFN-y production
IL-12
Response to inflammation. Cellular attempt to contain an offending agent that is difficult to eradicate
Granuloma formation
