Central Nervous System Flashcards
Enlargement of the entire ventricular system
Communicating hydrocephalus
Normal pressure hydrocephalus
Dilation of the ventricular system with a compensatory increas in CSF volume
Hydrocephalus Ex Vacuo
Dictates that any increase in volume of cranial constituents must be compensated by a decrease in volume of another
Monroe-Kellie Doctrine
Unilateral expansion of a cerebral hemisphere displaces the cingulate gyrus under the falx ceribiri leading to compression of the branches of the anterior cerebral artery
Subfalcine (cingulate) herniation
Medial temporal lobe compressed against free margin of tentorium leading to CNIII and posterior cerebral artery compression
Transtentorial herniation
Hemorrhagic lesions in midbrain and pons occurring during transtentorial herniation
Duret hemorrhages
Life-threatening herniation that causes brainstem compression which compromises vital respiratory and cardiac centers in the medulla oblongata
Tonsillar herniation
Neural tube defect with diverticulum of malformed tissue extending through a defect in the cranium
Encephalocele
Failure of closure of posterior neuropore causing asymptomatic bony defect or sever cord malformation with meningocele
Spina bifida (aka spinal dysraphism)
Extension of CNS tissue through a defect in the vertebral column
Myelomeningocele
Absence of the brain and calvarium. There is a flattt ned remnant of disorganized brain tissue (area cerbrovasculosa)
Anencephaly
Non-progressive neurologic deficit attributable to hypoxic insults during the prenatal and perinatal periods
Cerebral palsy
Cord malformation associated with Chiari I malformation
Syingobulbia
Formation of fluid-filled cleft-like cavity in the inner portion of the cord
Syringomyelia
Fluid-filled cavity that extends from cord to brainstem
Syringobulbia
Thinning out of gyri due to cortical ischemia
Ulegyria
Marbolization of deep nuclei due to ischemia & gliosis
Status marmoratus
Supratentorial periventricular white matter infarct with chalky yellow plaques
Perivetricular leukomalacia
Cystic infarcted lesions in the brain. Multiple cavities traversed by a web of delicate glial strands.
Multicystic encephalopathy
Acceleration-deceleration injury at the site of impact
Coup injury
Acceleration-deceleration injury opposite the site of impact
Countercoup injury
Parenchymal brain injury with pericapillary edema and extravasation
Contusions
Parenchymal brain injury, depressed retracted yellow brown patches involving the crests of gyri (placque jaune)
Old traumatic lesions
Wide asymmetric axonal swelling with gliosis and degeneration
Diffuse axonal injury
Arterial bleed which creates a blood-filled space between the bone and dura. Lenticular on CT-scan. Manifests wi lucid interval and rapid deterioration
Epidural hematoma
Fracture of the pterion will lead to severance of this artery
Middel meningeal artery
Venous bleeding between the dura and arachnoid membranes. Crescent-shaped on CT-scan. Delayed presentation with fluctuating levels of consciousness.
Subdural hematoma
Outcome of severe hypotensive episode. Poor demarcation between gray and white matter. Microvacuolization and eosinophilia with reactive gliosis
Global cerebral ischemia
Focal cerebral ischemia with r d neurons, reactive gliosis, and liquefactive necrosis
White infarct
Parallel white infarcts but with extravasation and resorption of blood found in focal cerebral ischemia
Red infarcts
Development if small cavitary infarcts which resemble lace-like spaces in hypertensive cerebrovascular disease
Lacunar infarct
Common site of lacunar infarct in hypertensive cerebrovascular diseases
Lenticular nucleus (putamen and globus pallidus)
Rupture of small-caliber penetrating vessels that leaves behind slitlike cavity
Slit hemorrhages
Necrosisin a band-like pattern, with a relative preservation of cells immediately adjacent to the meninges
Pseudolaminar necrosis