Leucemias Generalidades Flashcards

1
Q

Marcadores de estirpe B

A

Positivos: CD19, CD 22, CD 79a, PAX5, PAX10, CD22, CD24, TdT.
Expresión Variable: CD13, CD20, CD33, CD34, CD45, IgMs

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2
Q

Marcadores de estirpe T

A

Positivos: TdT, CD3c, CD7

Expresión variable: CD1a, CD2, CD3s, CD4, CD5, CD8, CD10, CD19, CD33, CD34, CD56, CD79, CD99, CD 117.

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3
Q

Marcadores de LAL Pro-B

A

HLA-DR, CD19, CD22, CD79a, TdT.

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4
Q

Marcadores de LAL Pre-B

A

HLA-DR, CD10, CD19, CD22, CD79a, TdT.

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5
Q

Marcadores de LAL pre-B

A

HLA-DR, CD10, CD19, CD22, CD79a, TdT, IgM

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6
Q

Marcadores de LAL B-Madura

A

HLA-DR, CD10, CD19, CD22, CD79a, TdT, IgM, Igc

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7
Q

Marcadores de LAL Pro-T

A

CD3, CD7, CD34

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8
Q

Marcadores de LAL Pre-T

A

CD2, CD3, CD7, CD34

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9
Q

Marcadores de LAL T-cortical

A

CD1, CD2, CD3, CD4, CD8

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10
Q

Marcadores de LAL T-madura

A

CD2, CD3, CD4, CD7, CD8

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11
Q

Criterios de Riesgo estándar para LAL

A

Menos de 30 años

Leucos

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12
Q

Criterios de alto riesgo de LAL

A
>35 años
Leu>30
Alteraciones citogenéticas
LAL ProB
LAL Pro T/Pre T
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13
Q

Definición de Fase Crónica de LMC

A

Menos de 15% de blastos en MO (MD Anderson)

Menos de 10% de blastos en MO (OMS)

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14
Q

Definición de Fase Acelerada de LMC

A

16-29% de blastos en MO (MD Anderson)
10-19% blastos
Trombocitopenia ( 1000)
Aumento de Bazo

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15
Q

Definición de Fase Blástica de LMC

A

30% de blastos en MO

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16
Q

Definición de Respuesta Molecular Completa para LMC

A

Decenso de 2.5 log en PCR