Lesson 2.2 Flashcards
the study of how the effects of a drug are manifested
Pharmacodynamics
the study of the method or mechanism of drug action on living sites in the body tissues or the response of tissues to chemical agents at various dite in the body
Pharmacodynamics
refers to drugs
Pharmaco
refers to ehat happens when two things meet and interact that is the drug and your body
Dynamics
drugs produces effect through drug receptor interaction drug enzymes interaction or nonspecific drug interactions
Mechanism of Action
the method by which a drug elicits effect is known as the____
Mechanism of Action
receptor are specific biologic sites located on a cell surface or within a cell
Drug-Receptor Interaction
they can be considered keyholes into which specific keys may fit
Drug-Receptor Interaction
drugs have a specific affinity (attraction) for their receptors
Drug-Receptor Interaction
this means that there is an attraction between the drug and the receptor
Drug-Receptor Interactions
a drug with affinity for a particular receptor will attach to the receptor and produce n ____ ____ ____ _____
Drug-Receptor Interactions
agonistic, antagonistic, or mixed agonistic/ antagonistic response
if there is a strong affinity at the receptor site the concentration of the drug necessary to accomplish its effevt is ___
Drug-Receptor Interactions
Low
this is reffered to as the EFFICACY of the drug
Drug-Receptor Interactions
the organ on or in which the desired effect occurs
Target Organ
a drug or natural substance with an affinity for specific receptor sites that produces a physiologic response usually predictable
Agonist
it is the degree to which a drug is able to produce the desired effect (how great the effect will be)
Efficacy
the time required for the current serum drug concentration to decline by 50% is termed the biologic half life or hal life elimination
Half-Life
the relative concentration required to produced that effect (how much drug is needed)
Potency
a measure of the relative safety of a drug
Therapeutic Index
it is a ratio between the following two mathematical factors
Lethal Dose (LD50)
Effective Dose ( ED50)
a drug is lethal to 50% of the population
Lethal Dose (LD50)
required to produced a therapeutic effect in 50% of the population
Effective Dose (ED50)
how great the effect will be
Efficacy
much much drug is needed
Potency
