Lesson 2 PHARMACOKINETICS Flashcards
the study of the movement of drugs within biologic system includes Absorption, Distribution, Metabolisation and Extraction
Pharmocokinetics
drugs must be in liquid form to be absorbed
Absorption
drugs advance from dosage form into a form that makes it biologically available for passage into systemic circulation
Absorption
solid or tablet form drugs phase before absorption
Pharmaceutic phase
determine deciding whether drug will cross cell membrane
Passive Diffusion
Lipid and water solubility
Passive Diffusion
pinocytosis
Active Transport
cell engulf drug particle and form protective coat around and transport across cell membrane
Active Transport
orally taken drugs may be metabolized or become inactive large doses must be taken to attain intended effect
First-Past Effect
Rate of DISTRIBUTION depends on:
Adequate blood circulation
Protein binding
Drugs Affinity
process of alternation of structure of drugs or foreign substance
Metabolism
Factors that alter METABOLISM rates:
Age
Health Status
Time of day
Emotional Status
Presence of other drugs in the body
Genetic variation
Disease state
others site may be Biliary Tract, Feces, Enteroheoatic cycle later into the kidney, lungs, sweat and saliva, mammary glands
Excretion
kidneys are where the ____ commonly takes place
Excretion
process of drugs within the body depends on:
Age
Nutritional Status
Ethnicity
Existing Physical Condition
Immune Status
State of Mind
Gender
Weight
Environment Factor
Time of day
