Lesson 2 Pharmacodynamics Flashcards
Physiologic Effects of Drugs are Affected by the Following
Altered Blood Pressure
Altered Heart Rate
Altered Urinary Output
Altered Function of CNS and PNS
Changes in all other body system
macromolecular component of the body tissue that receives the maximum effect of a drug
Drug Receptor
determines drug concentration to accomplish intended attraction between drug and receptor
Affinity
concentration of drug to accomplish its intended effect
Efficacy of Drugs
bind to receptor and produces therapeutic effect
Agonist
partial binding at a receptor and produce partial therapeutic effect
Partial Agonist
joins receptor and prevents agonist from performing intended effects
Antagonist
dosage of which intended effect is obtained and the amount that produces unwanted effect
Therapeutic Index
Drug Combination or Combining Two Drugs may cause:
to become inactive
to form a toxic compound
to increase the effect of each drug given alone (additive reaction)
to equal an effect greater than sum of their separated dose (synergistic reaction)
to either neutralize or decrease intended effect
common, unintended, and non-toxic reactions
Side Effect
more severe and life threatening reactions
Adverse
unwanted effect that is extension of therapeutic effect
Toxic Reactions
unexpected or exacerbated effect
Drug Idiosyncrasy
sign of drug dependence
Drug Tolerance
rapid development of tolerance to a drug
Tachyphylaxis
results from an immune-mediated response by the body against the drug
Allergic Reaction
