Lecture4 Part One Flashcards
What is the most important and most spread in the plasma out of the complement proteins
It is c3
The membrane attack complex is composed out of
C5b C6 C7 C8 C9
What is the role of keratinocytes regardless producing keratin getting to the most apical layer to make a protection line
It also produce two cytokines which they re tnf and il8
What is the role of keratinocytes regardless producing keratin getting to the most apical layer to make a protection line
It also produce two cytokines which they re tnf and il8
Why is the thing that is distinctive about the micro flora
It’s a non pathogenic bacteria that lives in the sebum environment
It’s also important to compete the pathogen on the nut Erie T in the oral cavity
What does predispose mean
اكثر عرضة
How to treat the chronic fatigue syndrome
By dsrna (ampligen) it’s the strongest factor of producing the interferons
And interferons treat the syndrome
Give me an example of intracellular pathogens
Virus
Mycobacterium tuberculosis ( interferons type one fight against it )
Examples on collection and they are considered
Mel surfacatant considered humoral secreted not cellular innate immunity not adaptive
What is the opsinon and examples on
Molecules that triggers the phagocytosis by binding to the mo and by normally having a receptor on the phagocytic cells
Where do we mention the G ve bacteria
Our tears lysozymes break the cell wall of this bacteria
At the alternative pathway of complement activation
What the thing that interfere with the shedding and predispose us to the infection
Corticosteroids
What are the causes of the recurrent infections like the respiratory infection
Cystic fibrosis
Primary cilliary dyskinesia disorder
When we are going to be more suspecting the salmonella infection
When the stomach acidity decrease
What treat the following
Chronic fatigue syndrome
Viral hepatitis
Chronic myeloid leukemia cancer
1-dsrna withoutالعوامل الممرضة
2- recombinant alpha interferons
Who produces interferons type1and2
1is the same virally infected cell
2is the nk cells and th1
A clinical note to the interferons type one
It kill the mycobacterium tuberculosis
The regulation of the C3boccurs by what and what is the final product
Factor h and I
C3c C3dg
What are the anaphylactoxin components of the complement what their functions are
C3a c4a c5a only
1-increases leukocytes adhesion
2-increase bv permapility by kin in by c2a
3-degranulation and phagocytosis
4- chemotactic factors c5a for neutrophils
What is the importance of the complement system
Anaphylatoxin and chemotactic factors
Lysis تقريبا لازم نعرف بجسم الإنسان بس ال nisseria why?
Degranulation of mast cells by c3a and c5a
Stimulation of b lymphocyte by c3d has receptor on B cells called CR2 which when c3d bind to decrease the activation threshold ,CR2 could bind to epistein Barr virus cause to B cells a disease called mononuclease
Clearance of the immune complexc3b c4
Opsinosation by c3b c3dg that has receptors on phagocytic cells which are CR1 CR3 CR4
أي صفا ال opsinon همه: الig and collectin and cb3 and c3dg
Mention all of the complement inhibitors
Cd55(adf):disassociate c3 cnvertase either c3bBb orc2ac4b
Cd59:membrane bound to c8 andc9 thus prevent the formation of mac
C1 inhibitor prevent the activation by the classical pathway
C3 inhibitor membrane bound or soluble inhibitor
Fh and fi to inhibit the c3b coming out of the alternative pathway
Mention all of the complement inhibitors
Cd55(adf):disassociate c3 cnvertase either c3bBb orc2ac4b
Cd59:membrane bound to c8 andc9 thus prevent the formation of mac
C1 inhibitor prevent the activation by the classical pathway
C3 inhibitor membrane bound or soluble inhibitor
Fh and fi to inhibit the c3b coming out of the alternative pathway
What the deficiency of cd55(daf) and cd59
paramoxyl hemoglobinuria
What the deficiency c1 inhibitor makes
It is heredity makes angiodema
What the defecincy of c3 inhibitor membrane bound makes
Atypical hemolytic Uric syndrome
What will occur if there is a deficiency in any complement system
Recurrent bacterial infection because of the immunodeficiency
What will occur if there is deficiency in the early complement ex c3b
An autoimmune disease that is called SLE systemic lupus erythronia
What will occur if there is a deficiency in early lectin or classical pathway
Less immune complex clearance and thus cause type 11 l three hypersensitivity
What will occur if there is a deficiency in the late complement C5-C9 MAC
Meningitis because of nisseria in infection
What will occur if there is a deficiency in the late complement C5-C9 MAC
Meningitis because of nisseria in infection
Give me some examples on opsinon
Igs ( the soluble ones only)
Collections ( remember they are considered secreted( humoral) recognition molecules)
Give me some examples on opsinon
Igs ( the soluble ones only)
Collections ( remember they are considered secreted( humoral) recognition molecules)
About opsinon
The opsinon bind to the mo and the phagocytic cells ( specifically on its receptor )to facilitate the phagocytosis but also the opsinon could bind to the microorganism and a complement instead of the phagocytic cells
