Lecture4 Part One

Question 1

What is the most important and most spread in the plasma out of the complement proteins

Answer 1

It is c3

Question 2

The membrane attack complex is composed out of

Answer 2

C5b C6 C7 C8 C9

Question 3

What is the role of keratinocytes regardless producing keratin getting to the most apical layer to make a protection line

Answer 3

It also produce two cytokines which they re tnf and il8

Question 4

What is the role of keratinocytes regardless producing keratin getting to the most apical layer to make a protection line

Answer 4

It also produce two cytokines which they re tnf and il8

Question 5

Why is the thing that is distinctive about the micro flora

Answer 5

It’s a non pathogenic bacteria that lives in the sebum environment
It’s also important to compete the pathogen on the nut Erie T in the oral cavity

Question 6

What does predispose mean

Answer 6

اكثر عرضة

Question 7

How to treat the chronic fatigue syndrome

Answer 7

By dsrna (ampligen) it’s the strongest factor of producing the interferons
And interferons treat the syndrome

Question 8

Give me an example of intracellular pathogens

Answer 8

Virus
Mycobacterium tuberculosis ( interferons type one fight against it )

Question 9

Examples on collection and they are considered

Answer 9

Mel surfacatant considered humoral secreted not cellular innate immunity not adaptive

Question 10

What is the opsinon and examples on

Answer 10

Molecules that triggers the phagocytosis by binding to the mo and by normally having a receptor on the phagocytic cells

Question 11

Where do we mention the G ve bacteria

Answer 11

Our tears lysozymes break the cell wall of this bacteria
At the alternative pathway of complement activation

Question 12

What the thing that interfere with the shedding and predispose us to the infection

Answer 12

Corticosteroids

Question 13

What are the causes of the recurrent infections like the respiratory infection

Answer 13

Cystic fibrosis
Primary cilliary dyskinesia disorder

Question 14

When we are going to be more suspecting the salmonella infection

Answer 14

When the stomach acidity decrease

Question 15

What treat the following
Chronic fatigue syndrome
Viral hepatitis
Chronic myeloid leukemia cancer

Answer 15

1-dsrna withoutالعوامل الممرضة
2- recombinant alpha interferons

Question 16

Who produces interferons type1and2

Answer 16

1is the same virally infected cell
2is the nk cells and th1

Question 17

A clinical note to the interferons type one

Answer 17

It kill the mycobacterium tuberculosis

Question 18

The regulation of the C3boccurs by what and what is the final product

Answer 18

Factor h and I
C3c C3dg

Question 19

What are the anaphylactoxin components of the complement what their functions are

Answer 19

C3a c4a c5a only
1-increases leukocytes adhesion
2-increase bv permapility by kin in by c2a
3-degranulation and phagocytosis
4- chemotactic factors c5a for neutrophils

Question 20

What is the importance of the complement system

Answer 20

Anaphylatoxin and chemotactic factors
Lysis تقريبا لازم نعرف بجسم الإنسان بس ال nisseria why?
Degranulation of mast cells by c3a and c5a
Stimulation of b lymphocyte by c3d has receptor on B cells called CR2 which when c3d bind to decrease the activation threshold ,CR2 could bind to epistein Barr virus cause to B cells a disease called mononuclease
Clearance of the immune complexc3b c4
Opsinosation by c3b c3dg that has receptors on phagocytic cells which are CR1 CR3 CR4
أي صفا ال opsinon همه: الig and collectin and cb3 and c3dg

Question 21

Mention all of the complement inhibitors

Answer 21

Cd55(adf):disassociate c3 cnvertase either c3bBb orc2ac4b
Cd59:membrane bound to c8 andc9 thus prevent the formation of mac
C1 inhibitor prevent the activation by the classical pathway
C3 inhibitor membrane bound or soluble inhibitor
Fh and fi to inhibit the c3b coming out of the alternative pathway

Question 22

Mention all of the complement inhibitors

Answer 22

Cd55(adf):disassociate c3 cnvertase either c3bBb orc2ac4b
Cd59:membrane bound to c8 andc9 thus prevent the formation of mac
C1 inhibitor prevent the activation by the classical pathway
C3 inhibitor membrane bound or soluble inhibitor
Fh and fi to inhibit the c3b coming out of the alternative pathway

Question 23

What the deficiency of cd55(daf) and cd59

Answer 23

paramoxyl hemoglobinuria

Question 24

What the deficiency c1 inhibitor makes

Answer 24

It is heredity makes angiodema

Question 25

What the defecincy of c3 inhibitor membrane bound makes

Answer 25

Atypical hemolytic Uric syndrome

Question 26

What will occur if there is a deficiency in any complement system

Answer 26

Recurrent bacterial infection because of the immunodeficiency

Question 27

What will occur if there is deficiency in the early complement ex c3b

Answer 27

An autoimmune disease that is called SLE systemic lupus erythronia

Question 28

What will occur if there is a deficiency in early lectin or classical pathway

Answer 28

Less immune complex clearance and thus cause type 11 l three hypersensitivity

Question 29

What will occur if there is a deficiency in the late complement C5-C9 MAC

Answer 29

Meningitis because of nisseria in infection

Question 30

What will occur if there is a deficiency in the late complement C5-C9 MAC

Answer 30

Meningitis because of nisseria in infection

Question 31

Give me some examples on opsinon

Answer 31

Igs ( the soluble ones only)
Collections ( remember they are considered secreted( humoral) recognition molecules)

Question 32

Give me some examples on opsinon

Answer 32

Igs ( the soluble ones only)
Collections ( remember they are considered secreted( humoral) recognition molecules)

Question 33

About opsinon

Answer 33

The opsinon bind to the mo and the phagocytic cells ( specifically on its receptor )to facilitate the phagocytosis but also the opsinon could bind to the microorganism and a complement instead of the phagocytic cells