Lecture 6 Mcqs

Question 1

What is the type or types of mhc classes found in the respiratory epithelium

Answer 1

It is class one mhc only cause it is epithelial cells so normal neucleated cells only there it is not an antigen presenting cell

Question 2

Is class three mhc encoded
And class two all of it
And class one all of it

Answer 2

Class three is mhc encoded and note some examples of class three mhc we have c2 c4 tnf but c3 is not a part of it
Class two all of it is mhc encoded but only alpha and beta one that they are polymorphism
Class two just alpha chain that is mhc encoded but beta chain is not mhc encoded and the third segment of class three is actually not polymorphism it is just the first and second segments that they are polymorphism

Question 3

The hla a and hla b and hla c hla e hla f hla g are genes each on in a different locus in chromosome 6
When get detailed types of them will be allele in different locus
But the hla dp hla p dq hla dr hla dm hla do
These are genes even the detailed types of them are genes not mentioned as alleles ex hla b has 469 alleles so it is a gene that has lots of alleles
But hla drb2 is a gene even if detailed it has 239 alleles
But hla ab3 for example is an allele
That’s it

Answer 3

Thx love it

Question 4

Is nk cell and nk T lymphocyte out of amyloid or lymphoid lineage

Answer 4

They are out of a lymphoid lineage

Question 5

What is cd1

Answer 5

It is a surface marker
That is not mhc encoded but look alike mhc class one
It display the ag specifically the lipid ag for the nk T lymphocyte

Question 6

Is cd 40 on surface of T lymphocyte or antigen presenting cells

Answer 6

Cd 40 ligand is produced by the T lymphocyte but cd40 is on the surface of apc so the interaction between the T lymphocyte and antigen presenting cell is bidirectional so when cd40l bind to cd40 it will make cd80 b7 on the antigen presenting cell and the positive amplification loop will keep gong

Question 7

Also what about b71and b72

Answer 7

Cd 80 and cd86 these both consider a ligand for the costimulatory receptors on the tcr the costimulatory receptor is cd 28

Question 8

What is the thing that has itsms

Answer 8

It is slam family of the costimulatory receptor on the surface of the tc

Question 9

Mutation in the transcription factor ciita will lead to

Answer 9

Bare lymphocyte syndrome

Question 10

Class one mhc is expressed more with the help of which cytokines also class two mhc

Answer 10

Class one mhc is with the help of inf type one
And class two with the help of inf type two gamma

Question 11

What is the percentage of gamma delta T lymphocyte and talk about them and what is the precentage of the alpha beta T lymphocyte

Answer 11

Gamma delta tc is 5 percentage and they are a rare type of the tc but they bind to small phosphorylated molecules and alkyl amine
But alpha beta is 95 percentage

Question 12

Ention the things that belong to ig superfamily

Answer 12

It’s antibodies
The tcr specifically the ligand binding domain
Bcr same as antibodies

Question 13

What do we mean by a pocket structure

Answer 13

Pocket structure is the groove either for the mhc or for the T cell receptors what ever

Question 14

What do we mean by the anchor residue

Answer 14

It is the amino acid residues of the peptide that anchor this peptide to the mhc molecule or the tcr it just anchors it

Question 15

Give me an example of class three mhc molecule

Answer 15

Hla dm but it looks alike class two mhc

Question 16

Does the cd40 could be expressed on the surface of T cell

Answer 16

No it doesn’t but it could be expressed on the surface of antigen presenting cells

Question 17

What transduce the signal in the bcr complex and T cell receptor complex

Answer 17

It is the accessory molecules
From the bcr it is ig alpha ig beta heterodimer cd79
For the tcr it is zeta chains homodimer cd247 and the cd3 chains

Question 18

Hla dm is

Answer 18

Class three mhc so mhc encoded

Question 19

Cd1

Answer 19

Is similar to hla 1 and non mhc encoded