Lecture Five Flashcards
What igs are considered B cell receptors
They are igm(the membrane bound one) and igd (it’s always membrane bound cannot be secreted(
What is the ig isotope that triggers the mast cell to degraulate
What is the on for the classical pathway activation c1q
Ige
Igm and igG
True or false igG appears early in the primary immune respinse
False
Which igs are 3 constant regions in the heavy chains and which are 4(we are talking about a one unit (monomer))
3(igG igd iga )
4(igm ige)
What is the main class of natural antibidies
Igm
What is the cause of flexibility in the antibody يعني يجعل الجسم المضاد قادر على الربط ب
epitopes for polyvaelant antigens and the epitopes are far away from each other
It’s the hinge region (it’s the cause of the presence of different igG subtypes)
And the ability of the variable region of heavy chain to rotate
What do they mean by a mono poly bi valent interactions
It’s is how much the one antibody with its different ag binding sites able to bind to different epitopes accorrding to how many ag binding site it does have and how the spread of ag epitopes is
Idiotyoe concerned with the variable region of both h and l chains
Allotype concerned with the constant regions
From different species concerned with the constant region and the framework of the variable region
Correct
Correct
Correct
What is the cause of a higher half life of the igG
What could increase its half life more
What is the drug that contain it and treat the ra (mention other things that treat it)
Binding to the neonatal fc receptor
By making injected fusion protein
Ctla4ig(active protein segment with an fc segment of igG)(the monoclonal antibody against the tnf)
The most ig isotype produce by a healthy person is
The most variable cdr is
Iga
Cdr3
Binding the ag to ab is covalent or non
Non covalent
Binding the ag to ab is covalent or non
Non covalent
What are the antibodies mediated effector functions
Osinaization ) for phagocytosis
Neutralize the toxins
Ab dependent cellular toxicosity
Ab mediated mast cell activation for degranulation
Activation of the complement (igm and igG for c1q activation for classical pathway)
تذكري igm and ige only has four constant regions in the heavy chain
Igd and igm only membrane bound (and when we say membrane bound that bind to the B cell surface as a B cell receptors ,and we don’t mean when they cross from the inside of plasma cell to outside when they are synthesised when they just cross the membrane like the secreted igs ,and also we don’t mean when the secreted ig neutralize an ag and decide to bind to a cell surface or complement or whatever to do the effector function no )
We just mean membrane bound ig binding to the surface of B cell they are B cell receptors
Is the antibody processed by the Pepsin able to bind to an fc receptor
No it cannot because the fc part became fragment
What is the thing that will not affect the antigen immunogenicity
The genetic background
