Lecture 5 Mcqs Flashcards
Which of the ig isotypes is going to be present in the neonatal intestine
It is igG because iga is going to be got with the breastfeeding but note that it’s not absorbed
But the igG is crossing the placenta blood barrier so it’s absorbed and also it absorbed when it goes to neonatal intestine by the breastfeeding
What treat the RA
What going to treat it is a mnonclonal antibody against the tnf(yes it’s good till large amounts in RA)
And also it could be treated by the ctla4 igG
Crp increase in the RA but that does not mean it is bad or a cause for the disease
What is the most importantly ig in complement activation
It is igm and mentioned earlier igG( two of it we need two fc fragment atleast for the c1q activation in the complement parhway)
Tail peice of the ig (secreted)
It is hydrophilic amino acids
Long in igm
Short in igG
Cytoplasmic part of the membrane bound ig
They are all positively charged
It is short in igm and igd
Long in igG and Ige
The j chain is binding to the tail precise when we make the multimeters of igs with which type of bound
Disulfide bound
What could treat leukemia cancer
Recombinant inf type alpha would treat it and treat viral hepatitis
An ab against cd20 would treat leukemia cancer and autoimmune disorders
What could be the problem of monoclonal antibody transferring
Serum sickness at the end which is primarily HAMA( human anti mouse antibody)
The only one that has two form secreted if the ig is
Iga has dimer and monomer
What is the hapten
It is a small free molecule that is not immunogenic but after immunization they become immunogenic (epwhen we add protein or polysaccride to it )
What do we call the epitopes
Examples on the poly valent antigen and un polyvalent ag
It’s the antigenic determinet
Un globular protein
Macromolecules polysaccharide nuclei acid cell surface
Mention the types of epitopes
Confirmational folded it is really big cdrs need to space up to accommodate it
Linear epitopes(could be in the internal or external surface of the whole ag)
The new epitopes post modification
Mention the types of epitopes
Confirmational folded it is really big cdrs need to space up to accommodate it
Linear epitopes(could be in the internal or external surface of the whole ag)
The new epitopes post modification
Dissociation constant is for what
For the affinity
Mention large and small epitope
Large confirmational or folded epitopes
Small drugs or monosaccharides
