Lecture 4 Mcqs Flashcards
What cause paroxysmal nocturnal hemoglobinuria
Deficiency of daf cd55 and cd59
What cause angiedema
What cause atypical hemolytic urimec syndrome
Deficiency of c1 inhibitor
Deficiency of c3 inhibitor
What cause systemic lupus erythrmotosous
Deficiency of a complement any one in the early steps(autoimmune disease)
A maturation in the gene of the fas ligand will cause
Autoimmmune lymphoproliferative syndrome
Poly morphonuclear
And mono morphonuclear
Are neutrophils basophil esinophile
Are monocytes lymphocytes
Tell me about what produce from their lineage and what activate them to do the function for the following:
Natural killer cells
Mast cell
Esinophile
Nk cell is activated by il2 and il12 and inf alpha and beta it is activated by binding igG that is cross linked with the viral ag with the fcgammar111 ( unlike mast cell fc receptor)
Mast cell from the myeloid lineage by il3 and il4 by th2 and has a receptor for the ige that bind to it before the cross linking with the ag but not activated ( the mast cell) till ag bound to it it produces cytokines like tnf and il4 for th2 activation and il3 and il5 for esinophile production also activated by the anaphylatoxic complement
Esinophile production mentioned earlier and activation by chemokines and sometimes fc receptor bound to it ige same way as the mast cell
What dies inf gamma does
Increase the mhc expression on normal cells and increase nk cell activity
Cd 94 is an
Cd14 is an
Cd44 is an
Inhibitory receptor for nk cell
Marker for the macrophage
Marker for the pluripotent cell
What causes granuloma
Chronic infection by the macrophage
What trigger the ohagocytosis for the phagocytic cells
Binding the ag to the prr or mostly binding the opsinosed ag ( with complement or igG)
Mention all of the opsinon
Complement (c3b c3dg with the receptor cr1 cr3 cr4 on the phagocytic cell)
Soluble ig ( not the membrane on that works as receptor)
C reactive p
Collectin ( considered humoral secreted pattern recognition molecules in the innate immunity)
CpG drug
It triggers tlr 9 that will produce il12 and activate th1 with binding it to vaccines will treat cancer and activate lymphocyte
Remember th cell 2 just in esinophile and mast cell
il7 and tnf
il8 tnf
il8 and il1 tnf
il1 il6 and tnf
il2 il12 inf1
il3 il4
il3 il5
il12 tnf
Inf2 and th1
By T suppressor cells
Deep living keratinocytes
Macrophage for neutrophils recrutiment
Macrophage for helping liver produce crp
Activat nk cells
Production of mast cell by th2
Produced by th2 and mast cell for the production of esinophile
By macrophage to help in activation of macrophage
Receive them macrophage to help in costimulation of the adaptive immunity
Does fibronigen increase in the acute phase reaction
Yes it does and produced by the liver
In alternative pathway what is the enzymatic part of the c3 convertase
Factor b
