Lecture Four Part Two Flashcards
What il8 remind you of
It reminds me of il8 and tumor nf produced by the deep living keratinocytes wto help in injury healing
What cytokines macrophage produces
Il1 il8 il12 tnf
What are the cytokines produced by macrophage
Tnf
Il8
Il1
How to stimulate the bone marrow in transplantation
Using recombinant of G csf
And GM csf
The differentiation of cd34
It is depending on car and cytokines and tnf
What cytokines macrophages produce and what their function
Il1 il8 tnf for neutrophils recrutiment
Il1 il6 tnf for increasing things for the acuate phase reactant’s crp complement fibrinogen
What recruit the neutrophils
Il17 out of th17 il1 il8 tnf out of macrophage c5a (anaphylatoxin)
What is the cause of chronic granulomatoyse disease
Deficiency in nadph and thus it will affect the respiratory burst in the killing mechanism of macrophage and pmn
What produce the inflammatory mediators and mention them
Pmn and macrophage produce inflammatory mediators such as :leukotrreins and prostaglandin
What form the bus
The polymorphoneuclear after they die( short lived ) the protyolitic enzymes doesn’t regenerate at but it does regenerate in macrophages because they are long lived and
What is the cell that is concerned with the chronic inflammation
The macrophage long living
Nk cells activated by what and produce what
It’s activated by il12 il2 inf type one and produces inf type two
What is the difference between nk cells and c cytotoxic cells in function as long as both are killing virally infected cells and tumor cells
Firstly T cells in general they don’t work except if the ag is presented on the surface of apc(جايبيتله الضد) or the infected cell itself(عارضه الضد يلي مؤثر عليها على سطحها)
And to know that the virus decrease mhc expression same as the the tumor cells so less mhc is presented so cd8 can’t work here but nk cells work like in herpvruis
But influenza virus for example increase mhc expression so cd8 fight it not nk cell
فلازم الcd8 الورم أو الضد يعرض عن طريق أم اشج سي
What is the crp effect
Opsinon activation of the complement and activation of the adaptive immunity
Chronic granulomatous disease
Septic shock
Reasons
Nadph deficiency
كميات كبيرة من ال nitric oxide
