Lecture20: Local Anesthetics

Question 1

What are both esters?

Answer 1

Benzocaine, procaine

Question 2

What are both amides?

Answer 2

Lidocaine, bupivacaine

Question 3

Which is more potent and lipid soluble?

Answer 3

Amide

Question 4

What is metabolized by Plasma pseudocholinestrase?

Answer 4

Ester

Question 5

What is metabolized by the liver?

Answer 5

Amides

Question 6

What is likely allergic?

Answer 6

Esters

Question 7

Which voltage gated channels are blocked?

Answer 7

Sodium channels

Question 8

From which side are those NA+ channels blocked?

Answer 8

Intercellular

Question 9

What LA has the greatest protein binding property and the longest acting?

Answer 9

Bupivacaine

Question 10

Name a vasoconstrictor

Answer 10

Adrenaline

Question 11

What does vasoconstriction do?

Answer 11

Reduces blood flow, increases toxicity, reduces absorption

Question 12

Which fibres are blocked first?

Answer 12

A delta and C

Question 13

Which type of fibres are blocked first?

Answer 13

Myelinated

Question 14

Which fibre has a high sens to block?

Answer 14

C fibres

Question 15

What LA is administered topically?

Answer 15

Benzocaine

Question 16

Which LA is injected?

Answer 16

Lidocaine

Question 17

Where are nerve blocks injected?

Answer 17

Around the nerve trunk proximal to area of intended anesthesia

Question 18

What does CNS Toxicity present as?

Answer 18

Tinnitus, dizziness, convulsions

Question 19

Which LA is most cardiotoxic?

Answer 19

Bupivacaine

Question 20

Which LA type is most common cause for anaphylaxis?

Answer 20

Esters