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blood bank > lecture questions exam 3 > Flashcards

lecture questions exam 3 Flashcards

1
Q

which cell is the best to remove auto antibodies in patient plasma using adsorption procedures
- sc1
- sc2
- sc3
- patient cell

A

patient cell
-> reacts with self to reveal underlying alloantibodies

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2
Q

for elution procedures, which step ensures that the washing was appropriate
- addition of Coombs control cell after anit-AHG
- testing of last wash with screen cells
- testing of elute with panel cells
- color change from yellow to blue with buffer

A

testing of last wash with screen cells

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3
Q

what DAT results are most consistent with a diagnosis of CAD

A

positive poly reaction and C3d, negative IgG
- Poly is specific for compliment and IgG
- col autoimmune = IgM = IgG will be negative

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4
Q

penicillin given in massive doses has been associated with RBC hemolysis. Which of the classic mechanisms is typically involved in this hemolytic process
- Immune complex
- Drug adsorption
- membrane modification
- autoantibody formation

A

drug adsorption

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5
Q

which step of the elution procedure is different in comparing these three procedures: Lui-Freeze, Acid Elution and Heat Elution

A

process for antibody removal from the cell
- wash step in all 3 removes unbound antibody from plasma

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6
Q

which auto-antibody is indicated when DAT results are positive with anti-C3d but negative with anti-IgG

A

cold

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7
Q

___ detects antibodies on the cell in vivo, while ___ puts antibody on cells in vitro

A
  • DAT: in vivo
  • IAT: in vitro
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8
Q

true or false:
Quality control results for a neutralization procedure should produce negative agglutination reactions with panel cells

A

false
- neutralization quality control will show positive agglutination
- adsorption quality control will show negative agglutination

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9
Q

which of the following is NOT an interpretation from a negative agglutination reaction
- The Unite is compatible
- The Unit does not have the antigen
- The patient does not have the antigen
- the antibody is ruled in

A

the antibody is ruled in

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10
Q

which test would most help distinguish if the cold antibody identified is benign or pathologic
- test with cord cell
- test an enzyme-treated panel
- antibody titer
- DAT

A

antibody titer

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11
Q

based on listed properties, is this a cold or warm hemolytic anemia
- most common specificity is Anti-I
- DAT is C3 pos
- purple extremities
- intravascular hemolysis
- reacts at IS

A

cold

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12
Q

based on listed properties, is this a cold or warm hemolytic anemia
- extravascular hemolysis
- reacts at AHG
- DAT is IgG pos
- extremely low hemoglobin values
- most commonly anti-e

A

warm

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13
Q

if an antibody reacts at all phases but negative with cord cells it is most likely:
- anti-H
- anti-IH
- anti-i
- anti-I

A

anti-I

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14
Q

match the drug responsible for: drug adorsption
- cefotetan
- quinidine
- cephalosporin
- aldomet

A

cefotetan
- also streptomycin and penicillin

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15
Q

match the drug responsible for: immune complex
- cefotetan
- quinidine
- cephalosporin
- aldomet

A

quinidine
- also phenacetin

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16
Q

match the drug responsible for: membrane modification
- cefotetan
- quinidine
- cephalosporin
- aldomet

A

cephalosporin

17
Q

match the drug responsible for: drug independent
- cefotetan
- quinidine
- cephalosporin
- aldomet

A

aldomet

18
Q

if you have a DAT result that is IgG negative and compliment positive, and the serum in the sample is tea colored, what should you suspect is causing this
- WAIHA
- immune complex with a drug
- Darzalex
- nonspecific cold agglutinatin

A

immune complex with a drug
- drug induced antibodies appear like warm auto antibodies
- hemolysis is characterized by tea colored plasma

19
Q

other than transfusion, what treatment might help a patient with autoimmunehemolytic anemia?
- plasma exchange
- antibody titer
- emergency release of O negative blood
- antibody adsorption

A

plasma exchange
- removes auto antibodies from patient

20
Q

a positive donath landstener result indicates which diagnosis
- WAIHA
- PCH
- PNH
- CAD

A

PCH: paroxysmal cold hemoglobinruia
- anti-P in urethra

21
Q

which of the following tests DOES NOT have to be performed for a patient to receive an electronic crossmathc
- Unit ABO retype
- blood type on previous sample
- antibody screen on current sample
- antibody screen on donor unit

A

anitbody screen on donor unit
- donor unit is only cells, cannot run an antibody screen
- abo retype on patient must be done and must match history
- patient must have a negative antibody screen

22
Q

after a unit is issued, how long does the nurse have to infuse the whole product into the patient
- 30 min
- 2 hr
- 4 hr
- 24 hr

A

4 hours
- transfusion must take 4 or less hours
- transfusion can begin right before expiration date on donor bag and still be fine

23
Q

which of the following components are acceptable to return to your blood bank inventory
- spiked, unused RBC w/ temp of 8C
- RBC w/ clot removed from the filter temp of 4.5C
- RBC with indicator dot red at 2.3C
- RBC out of blood bank for 30 min with white temp dot at 7.6C

A

rbc out of bank for 30min with white dot at 7.6C

24
Q

which of the following samples are acceptable for add-on crossmatch?
- 4 days old, A pos, neg screen
- 1 day old, O pos, pos screen
- 2 days old, nu current screen results
- 3 days old, AB neg, neg screen, history of anti-Fya

A

1 day old, O pos, pos screen
3 day old, AB neg, history Fya

25
Q

choose all that apply: under which circumstance would you warm a cross match
- A neg, neg screen , pos IS crossmatch
- O pos, anti-M ID
- O neg, anti-D ID
- ABO discrepancy, extra reverse reactivity

A
  • A neg, neg screen, pos IS crossmatch
  • O pos, anti-M
26
Q

the last 3 patients in a row have given eng reactions with anti-A, this type of error is most likely:
- coincidence
- pt sample error
- systematic error
- delta error

A

systematic

blood bank (16 decks)

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