blood groups Flashcards
Kidd system immunoglobulin type
IgG
true or false
the kidd system antigens can bind compliment
true
- IgG but can bind
enzyme effect on Kidd system
enhanced
Kidd system antigens
antithetical: Jka, Jkb
Jk3 present with a or b
-> cells will have Jka/b and 3
Kell system antigens
antithetical: K-k, Jsa-Jsb, Kpa-Kpb
frequency of kell system antigens
k, Kpb, Jsb: 100
K: 9
frequency of kidd system antignes
Jka: 75
Jkb: 75
JK3: 100
duffy system antigens
antithetial: Fya-Fyb
duffy system immunoglobulin type
IgG
enzyme interaction with duffy system antigens
destroyed by enzymes
special characteristics of duffy
duffy null prevents vivax entry
syntetic to Rh
- GATA 1 mutation = no duffy on red cells only (no antibodies made)
lutheran system antigens
- Lub: IgG
- Lua: IgM
chemical interaction with lutheran system
destroyed by DTT
special characteristics of lutheran
mixed field reactions
P system antigens
non antithetical: P1, P, Pk, p (null)
immunoglobulin type of P system
IgM -> normally anti P1
special characteristics of P
donath-landsteiner
gene codes for galactose transferase
MNS system antigens
M-N, S-s, U
MNS system nulls
Mk: whole system
Ena: MNS null but U pos
U: absence of glycophorin B
MNS system immunoglobulin type
M-N: IgM
S-s: IgG
enzyme reaction with MNS system
destroyed by enzymes
special consideration for MNS
dosage, M/N may react into 37 phase (significant), falciparum entry point
-> anti-N made transiently by dialysis patients
MNS system frequencys
M: 85
N: 70
S: 50
s: 90
U: 100
P system frequencies
P1: 80
P2: 100
p: 100
duffy system frequencies
Fya: 60
Fyb: 75
Fy3: 100
lutheran system frequencies
Lua: 5
Lub: 99
units to test formula
(100*units needed)/(100-antigen frequency)
what is on glycophorin A
- chromosome 4
- attaches M and N on the tail
what is on glycophorin B
S or s at the bottom
slight N on ends
U at base
what antigens are present in P1 phenotype
P1, P, Pk w/ no anti-P antibodies
describe the action of P1Pk gene
transferase adding galactose to end of sugar of type 2 forms pk antigen
- in competition with H fucosyltransferase
describe the glob gene
galactosaminyl transferase recognizing two galactoses to add a galnac => P antigen
Glob gene on chromosome 3
compare I and i
- I: branched, adults
- i: linear, fetal
describe auto anti-I
- most common cold agglutinin
- strong reaction with adults no reaction with fetal cells
- enhanced by poly-AHG
describe P antibodies
- anti-P1: naturally occurring IgM
- anti-P1PL: naturally occuring in Pnull (IgG)
what chromosome is Kell located
7
Kell null syndrome name
Mcleod - acanthocytes
role of XK
XK multipass protein with KX antigen
describe big I
internal portion of type 2 chains
branchy, adult form
related to M. pneumonia
describe little i
in infants, linear i
related to infectious mono
describe anti-I
auto-anti-I causing cold agglutination
-> agglutinates only with m. pneumonia infection, otherwise undetectable
describe anti-i
in infants after infectious mono infection
