blood groups summary Flashcards
1
Q
Rh system
A
- chormosome 1
- DCcEe
- enhanced by enzymes
- IgG
- reacts at AHG
- HDN
- null = spherocytes
2
Q
Kell system
A
- chromosome 7
- K-k, Kpa-Kpb, Jsa-Jsb
- destroyed by DTT, enhanced by enzymes
- IgG
- high and low incidence combo
- attached to XK protein w/ disulfide bonds
- null = Mcleod = acanthocytosis
- severe HDN and TRXN
- glycoprotein structure
3
Q
Duffy system
A
- chromosome 1
- Fya-Fyb
- destroyed by enzymes
- IgG
- AHG phase
- malaria vivax
- glycoprotein structure
4
Q
Kidd system
A
- chromosome 18
- Jka-Jkb
- enhanced by enzymes
- IgG
- Jka activates compliment
- dosage and titer
- delayed hemolytic transfusion reaction
5
Q
Lewis system
A
- chromosome 19
- Lea-Leb
- enhanced by enzymes
- IgM
- activates compliment
- Is and AHG
- carbohydrate chain structure
6
Q
MNS system
A
- chromosome 4
- M-N, S-s, U
- destroyed by enzymes
- IgM
- IS/AHG
- falciparum entry
- purpose: zeta potential
- sialic containing
- glycophorins made of glycoproteins
7
Q
P/Glob system
A
- PK synthase (PIPK) chromosome 22
- glob gene (P antigen) chromosome 3
- P1, p, Pk
- enhanced by enzymes
- P1: IgM
- big P: IgM (activates comp)
- anti-p1ppk: IgG
- anti P related to PCH
8
Q
lutheran
A
- chromosome 19
- Lua-Lub
- Destroyed by DTT
- Lua-IgM
- Lub- IgG
- mixed field reactions
- glycoprotein
9
Q
list blood group systems enhanced by enzymes
A
- Rh
- Kidd
- Lewis
- PGlob
- kell
10
Q
list blood group systems destroyed by DTT
A
- kell
- lutheran
- > both have disulfide bonds that hold them together and will be destoryed post treatment
11
Q
list blood group systems with IgG antibodies
A
- Rh
- Kell
- S-s part of MNS
- Lub
- Kidd
- Duffy
12
Q
list blood group systems with IgM antibodies
A
- Lewis
- M-N of MNS
- P system
- Lua
13
Q
list blood group systems whose antibodies can fix compliment
A
- anti-Jka
- lewis
- anti-P
- anti-S
14
Q
list glycoprotein antigen structured systems
A
kell
duffy
lutheran
15
Q
list carbohydrate chain antigen structured systems
A
Rh
MNS
lewis
P/glob
16
Q
list antibodies associated with hemolytic transfusion reactions
A
Rh
Duffy
kell (severe)
kidd (delayed)
anti-P
17
Q
list antibodies associated with hemolytic disease of the newborn
A
Rh
kell (severe)
duffy
S-s
18
Q
list antigens that are destroyed by enzymes
A
duffy
MNS
