blood groups summary Flashcards

1
Q

Rh system

A
  • chormosome 1
  • DCcEe
  • enhanced by enzymes
  • IgG
  • reacts at AHG
  • HDN
  • null = spherocytes
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2
Q

Kell system

A
  • chromosome 7
  • K-k, Kpa-Kpb, Jsa-Jsb
  • destroyed by DTT, enhanced by enzymes
  • IgG
  • high and low incidence combo
  • attached to XK protein w/ disulfide bonds
  • null = Mcleod = acanthocytosis
  • severe HDN and TRXN
  • glycoprotein structure
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3
Q

Duffy system

A
  • chromosome 1
  • Fya-Fyb
  • destroyed by enzymes
  • IgG
  • AHG phase
  • malaria vivax
  • glycoprotein structure
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4
Q

Kidd system

A
  • chromosome 18
  • Jka-Jkb
  • enhanced by enzymes
  • IgG
  • Jka activates compliment
  • dosage and titer
  • delayed hemolytic transfusion reaction
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5
Q

Lewis system

A
  • chromosome 19
  • Lea-Leb
  • enhanced by enzymes
  • IgM
  • activates compliment
  • Is and AHG
  • carbohydrate chain structure
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6
Q

MNS system

A
  • chromosome 4
  • M-N, S-s, U
  • destroyed by enzymes
  • IgM
  • IS/AHG
  • falciparum entry
  • purpose: zeta potential
  • sialic containing
  • glycophorins made of glycoproteins
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7
Q

P/Glob system

A
  • PK synthase (PIPK) chromosome 22
  • glob gene (P antigen) chromosome 3
  • P1, p, Pk
  • enhanced by enzymes
  • P1: IgM
  • big P: IgM (activates comp)
  • anti-p1ppk: IgG
  • anti P related to PCH
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8
Q

lutheran

A
  • chromosome 19
  • Lua-Lub
  • Destroyed by DTT
  • Lua-IgM
  • Lub- IgG
  • mixed field reactions
  • glycoprotein
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9
Q

list blood group systems enhanced by enzymes

A
  • Rh
  • Kidd
  • Lewis
  • PGlob
  • kell
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10
Q

list blood group systems destroyed by DTT

A
  • kell
  • lutheran
  • > both have disulfide bonds that hold them together and will be destoryed post treatment
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11
Q

list blood group systems with IgG antibodies

A
  • Rh
  • Kell
  • S-s part of MNS
  • Lub
  • Kidd
  • Duffy
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12
Q

list blood group systems with IgM antibodies

A
  • Lewis
  • M-N of MNS
  • P system
  • Lua
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13
Q

list blood group systems whose antibodies can fix compliment

A
  • anti-Jka
  • lewis
  • anti-P
  • anti-S
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14
Q

list glycoprotein antigen structured systems

A

kell
duffy
lutheran

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15
Q

list carbohydrate chain antigen structured systems

A

Rh
MNS
lewis
P/glob

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16
Q

list antibodies associated with hemolytic transfusion reactions

A

Rh
Duffy
kell (severe)
kidd (delayed)
anti-P

17
Q

list antibodies associated with hemolytic disease of the newborn

A

Rh
kell (severe)
duffy
S-s

18
Q

list antigens that are destroyed by enzymes

A

duffy
MNS