Immunology and Genetics Flashcards
IgM
- cold reactive
- large
- activates compliment
- hemmaglutination
- naturally occurring
IgG
- warm reactive
- small
- immune stimulated
haplotype
group of alleles inherited together
phenotype
serological presentation
genotype
inherited haplotype
membrane structure
52% protein
40% lipids
8% carbs
shift to the right
more oxygen delivered
- increased 2-3DPG, decreased oxygen affinity
shift to the left
decreased oxygen delivered
- decreased 2-3DPG, increase oxygen affinity
acid citrate dextrose shelf life
21 days
citrate phosphate desxtrose adenine shelf life
35 days
additive solutions shelf life
42 days
purpose of citrate in additive solutions
chelating calcium - prevents clotting
purpose of phosphate in additive solutions
maintains pH and 2-3DPG
purpose of dextrose in additive solutions
ATP substrate
purpose of adenine in additive solutions
produces ATP
which class of antibody reacts best at room temp
- IgG
- IgM
- IgE
- IgA
IgM
IgG antibodies are clinically significant for HDN because
o They are too big to escape the vein
o They fix compliment
o They demonstrate dosage
o They are small enough to cross the placenta
they are small enough to cross the placenta
Hemolysis is a positive reaction that indicates you have most likely identified antibodies that - reacts at AHG
- fix compliment
- cross the placenta
- are immune stimulated
fix compliment
in RBC storage, what is increased
plasma potassium and hgb, lactic acid
in RBC storage what decreases
- 2-3DPG
- glucose
- ATP
- viable cells
- pH
Which of the following is known as the membrane attack complex in the classical pathway?
- C1
- C3
- C4,2,3
-C5b,C6C7,C8,C9
C5b,C6C7,C8,C9
True or False:
Most Antigens we have discussed are inherited autosomal dominant
true
dosage
when expression of the antigen is less because of heterozygous inheritance of allele
