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blood bank > Immunology and Genetics > Flashcards

Immunology and Genetics Flashcards

1
Q

IgM

A
  • cold reactive
  • large
  • activates compliment
  • hemmaglutination
  • naturally occurring
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2
Q

IgG

A
  • warm reactive
  • small
  • immune stimulated
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3
Q

haplotype

A

group of alleles inherited together

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4
Q

phenotype

A

serological presentation

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5
Q

genotype

A

inherited haplotype

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6
Q

membrane structure

A

52% protein
40% lipids
8% carbs

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7
Q

shift to the right

A

more oxygen delivered
- increased 2-3DPG, decreased oxygen affinity

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8
Q

shift to the left

A

decreased oxygen delivered
- decreased 2-3DPG, increase oxygen affinity

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9
Q

acid citrate dextrose shelf life

A

21 days

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10
Q

citrate phosphate desxtrose adenine shelf life

A

35 days

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11
Q

additive solutions shelf life

A

42 days

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12
Q

purpose of citrate in additive solutions

A

chelating calcium - prevents clotting

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13
Q

purpose of phosphate in additive solutions

A

maintains pH and 2-3DPG

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14
Q

purpose of dextrose in additive solutions

A

ATP substrate

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15
Q

purpose of adenine in additive solutions

A

produces ATP

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16
Q

which class of antibody reacts best at room temp
- IgG
- IgM
- IgE
- IgA

A

IgM

17
Q

IgG antibodies are clinically significant for HDN because
o They are too big to escape the vein
o They fix compliment
o They demonstrate dosage
o They are small enough to cross the placenta

A

they are small enough to cross the placenta

18
Q

Hemolysis is a positive reaction that indicates you have most likely identified antibodies that - reacts at AHG
- fix compliment
- cross the placenta
- are immune stimulated

A

fix compliment

19
Q

in RBC storage, what is increased

A

plasma potassium and hgb, lactic acid

20
Q

in RBC storage what decreases

A
  • 2-3DPG
  • glucose
  • ATP
  • viable cells
  • pH
21
Q

Which of the following is known as the membrane attack complex in the classical pathway?
- C1
- C3
- C4,2,3
-C5b,C6C7,C8,C9

A

C5b,C6C7,C8,C9

22
Q

True or False:
Most Antigens we have discussed are inherited autosomal dominant

A

true

23
Q

dosage

A

when expression of the antigen is less because of heterozygous inheritance of allele

blood bank (16 decks)

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