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ABO Flashcards

1
Q

ABO antigens

A

carbs attached to red cell surface

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2
Q

chromosome for ABO

A

9

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3
Q

A antigen

A

N-acytlegalactose amine

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4
Q

B antigen

A

galactose

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5
Q

what does chrom 9 code for

A

transferase to place A or B antigen depending on gene

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6
Q

what does chrom 19 code for

A

FUT1,2,3 that code for transferase to put fucose on carb chains (RBC, secretions)

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7
Q

FUT 1

A

codes for type 2 substances

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8
Q

type 2 substances

A

RBC

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9
Q

FUT 2

A

codes for type 1 substances
- Se gene

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10
Q

type 1 substances

A

secretions

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11
Q

where is the secretion gene located

A

chrom 19

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12
Q

what does secretion gene do

A

codes for transferase to act on type 1 substances to make an H substance

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13
Q

H substance precursor chain (w/o fucoses)

A

(top)
gal
glc-nac
gal
glc

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14
Q

where does FUT 3 act

A

fucosyl transferase adds fucose to subterminal location on H chain
- lewis gene (Le)

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15
Q

lewis A

A

H substance without terminal fucose but with subterminal fucose = tot 1 fucose

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16
Q

lewis b

A

H substance with terminal fucose and subterminal fucose = tot 2 fucose

17
Q

how are secretions turned into A or B antigens

A

same transferase as RBC

18
Q

describe bombay patients

A

no H substance = no A, B or lewis expression

19
Q

most to least detectible H substance on antigens

A

O>A2>B>A2B>A1>A1B

20
Q

A1 subgroup

A

A transferase on straight and branchy
- pos anti A and Anti-A1 lectin

21
Q

A2 subgroup

A

A transferase only onto linear H branches
- pos w/ anti A
- neg a/ anti -A1

22
Q

A3

A

mixed field agglutination

23
Q

A(end)

A

weak anti-A agglutination = weak mixed field

24
Q

Ax

A

weak agglutination with only AB

25
Q

Am

A

A in saliva, anti-A neg

26
Q

Ay

A

small amt antiA in saliva

27
Q

Ael

A

needs elution to detect
- secretions only H substance

28
Q

B3

A

mixed field with anti B

29
Q

Bx

A

weakly reactive anti-B

30
Q

dolichos bifilarous

A

A1 specificity - flowers

31
Q

banderiea simplicifolia

A

B subgroup detection

32
Q

ulex eruopa

A

H substance detection (bombay/para)

33
Q

what determines secretor status

A
  • FUT2 on chromosome 19 making the type 1 secretion substance
34
Q

risky transplants

A

due to carbohydrates on secretions

35
Q

Le(ab)

A

antibody reacts with both Le(a) and Le(b)

36
Q

Le(bH)

A

antibody reactis with only Lewis b that do not have A or B sugar attached

37
Q

Ig identitidy of lewis antigens

38
Q

the immunodominant sugar responsible for group B specificity is

A

d-galactose

blood bank (16 decks)

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