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blood bank > auto immune hemolytic anemias > Flashcards

auto immune hemolytic anemias Flashcards

1
Q

list benign cold agglutinins

A
  • anti I: 0 rxn w/ cord cells
  • anti i: does mpt react with adult RBC
  • anti IH
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2
Q

describe CHD

A
  • mostly anti-I with wide thermal range
  • purple extremities
  • cold hemagglutinin disease
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3
Q

describe PCH

A
  • episodes of hgb uria after cold exposure
  • associated with syphilis, mumps
  • donath Landsteiner anti-P
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4
Q

describe the donath landsteiner test

A
  • pt serum, normal serum, mixed serum
  • 37 until tested
  • 37->0->37
  • check for hemolysis
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5
Q

which type of anemia is not often associated with comp activation
- PCH
- CAD
- drug adsorption
- WAIHA

A

drug adsorption

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6
Q

what is the special characteristic of drug induced antibody

A

tea colored plasma

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7
Q

describe drug adsorption mechanism

A
  • drug onto RBC membrane
  • Ab against drug destroys RBC
  • IgG no compliment
  • hemolysis
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8
Q

list DAT and eluate results for drug adsorption

A

IgG pos
C3 neg
eluate neg
hemolysis pos

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9
Q

name drugs related to drug adsorption hemolytic anemia

A
  • cefotetan
  • streptomycin
  • penicillin
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10
Q

describe immune complex mechanism

A
  • Ab and drug combine then attach to RBC
  • comp activated by complex
  • intravascular hemolysis
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11
Q

name DAT results from immune complex

A
  • IgG +/=
  • C3+
  • eluate neg
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12
Q

describe membrane modification mechanism of ation

A

drug nonspecifically binds RBC membrane so IgG, IgM and IgA attach
- nonimmune process
- no hemolysis

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13
Q

name DAT results for membrane modificatoin

A

IgG +
C3 +
eluate neg
hemolysis neg

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14
Q

describe drug independent anemia

A
  • autoantibody against drug alters T cells
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15
Q

name DAT results for drug independent anemia

A
  • IgG+
  • C3 +/=
  • eluate pos
  • hemolysi spos
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16
Q

list drugs related to drug independent anemia

A
  • aldomet
17
Q

name drugs resposinle for immune complex anemia

A
  • quinidine
  • phenacetin
18
Q

name drugs responsible for membrane modification anemia

A
  • cephalosporin
19
Q

describe chemo drug anemia

A
  • drug is the antibody against red cell
  • umab drug
  • weak pos to DAT poly and IgG
20
Q

how is diagnosis of drug adsorption induced antibody made

A

eluate and ABIF pos with drug coated panel cells only

21
Q

how is a diagnosis of immune complex antibodies made

A

patient serume + drug + ABO compatible blood = hemolysis

22
Q

how is a diagnosis of membrane modification antibodies made

A

everything else is ruled out
- no hemolysis

23
Q

how is a diagnosis of drug independent antibody formation made

A

history of drug use

24
Q

how is chemo drug detected

A

DTT removes antigen and ID becomes negative

blood bank (16 decks)

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