Lecture 9 - Threonine/Glycine/Serine Example

Question 1

Step 1a

Answer 1

Threonine -> acetaldehyde

Question 2

Step 2a

Answer 2

Acetaldehyde -> acetate

Question 3

Step 3a

Answer 3

Acetate -> acetyl CoA

Question 4

Step 2b

Answer 4

Glycine -> serine

Question 5

Step 3b

Answer 5

Serine -> pyruvate

Question 6

Step 4b

Answer 6

Pyruvate -> acetyl CoA

Question 7

Step 1b

Answer 7

Threonine -> glycine

Question 8

Enzyme of step 1b

Answer 8

Serine hydroxymethyl transferase (threonine aldolase)

Question 9

Cofactor of step 1b

Answer 9

None

Question 10

Enzyme of step 2b

Answer 10

Serine hydroxymethyl transferase (threonine aldolase)

Question 11

Cofactor of step 2b

Answer 11

FH4-CH2OH -> FH4

Question 12

Enzyme of step 3b

Answer 12

Serine dehydratase

Question 13

Cofactor of step 3b

Answer 13

NH3 out

Question 14

Enzyme of step 4b

Answer 14

Pyruvate dehydrogenase

Question 15

Cofactor of step 4b

Answer 15

• NAD+ -> NADH + H+

- CoASH -> CO2

Question 16

Enzyme of step 2a

Answer 16

Acetaldehyde dehydrogenase

Question 17

Cofactor of step 2a

Answer 17

NAD+ + H2O -> NADH + H+

Question 18

Enzyme of step 3a

Answer 18

Acetyl CoA synthetase

Question 19

Cofactor of step 3a

Answer 19

ATP -> AMP + PPi

Question 20

What enzyme converts AMP + PPi to 2 Pi and what is the cofactor?

Answer 20

• IPPase

- H2O in

Question 21

What enzyme converts ethanol to acetaldehyde and what is the cofactor?

Answer 21

• Alcohol dehydrogenase

- NAD+ -> NADH + H+