Lecture 14 - Serine/Glycine Synthesis Mechanism Flashcards
1
Q
Step 1
A
3-phosphoglycerate -> 3-phosphohydroxy pyruvate
2
Q
Enzyme of step 1
A
3-phosphoglycerate dehydrogenase
3
Q
Cofactor of step 1
A
NAD+ -> NADH + H+
4
Q
Step 2
A
3-phosphohydroxy pyruvate -> 3-phosphoserine
5
Q
Enzyme of step 2
A
Phosphoserine transaminase
6
Q
Cofactor of step 2
A
- PLP
- Glutamate -> alpha-ketoglutarate
7
Q
Step 3
A
3-phosphoserine -> serine
8
Q
Enzyme of step 3
A
Phosphoserine phosphatase
9
Q
Cofactor of step 3
A
H2O -> Pi
10
Q
Step 4
A
Serine -> glycine
11
Q
Enzyme of step 4
A
Serine hydroxymethyl transferase
12
Q
Cofactor of step 4
A
FH4 -> FH4-CH2OH
