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Biochem 2 > Lecture 5 - Regulation > Flashcards

Lecture 5 - Regulation Flashcards

1
Q

Why is regulation necessary?

A

Interconnection of pathways

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2
Q

What is a generalization that can be made about high energy molecules?

A
  • Slow down glycolysis and TCA cycle

- Turn on gluconeogenesis

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3
Q

What is a generalization that can be made about low energy molecules?

A

Increase glycolysis and TCA cycle

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4
Q

What activates phosphofructokinase?

A

AMP and ADP

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5
Q

What inhibits phosphofructokinase?

A

ATP and citrate

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6
Q

What activates fructose-1,6-bisphosphatae?

A

ATP and citrate

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7
Q

What inhibits fructose-1,6-bisphosphatase?

A

AMP and ADP

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8
Q

What activates pyruvate carboxylase?

A

Acetyl CoA

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9
Q

What inhibits pyruvate dehydrogenase?

A
  • Acetyl CoA
  • ATP
  • NADH
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10
Q

What activates pyruvate dehydrogenase?

A
  • Acetyl CoA
  • AMP
  • NAD+
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11
Q

What inhibits citrate synthase?

A
  • Succinyl-CoA
  • ATP
  • NADH
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12
Q

What activates citrate synthase?

A

ADP

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13
Q

What inhibits isocitrate dehydrogenase?

A

ATP

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14
Q

What activates isocitrate dehydrogenase?

A

ADP

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15
Q

What inhibits alpha-ketoglutarate dehydrogenase?

A
  • Succinyl-CoA

- NADH

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16
Q

What are the most common high energy signals?

A

ATP, NADH, and citrate

17
Q

How does ATP inhibit phosphofructokinase?

A

When it binds it lowers the affinity for fructose-6-phosphate

18
Q

How does ADP activate phosphofructokinase?

A

When it binds it raises the affinity for fructose-6-phosphate

19
Q

How many subunits does phosphofructokinase have?

A

4

20
Q

What molecules does phosphofructokinase have binding sites for?

A
  • Fructose-6-phosphate
  • ADP
  • ATP
21
Q

How is pyruvate dehydrogenase regulated?

A
  • Phosphorylation

- With a phosphate is the inactive form; without a phosphate is the active form

22
Q

What activates protein kinase?

A

NADH

Biochem 2 (40 decks)

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