Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Biochem 2 > Lecture 14 - Pyrimidine Synthesis > Flashcards

Lecture 14 - Pyrimidine Synthesis Flashcards

1
Q

Where does each atom of a pyrimidine come from?

A
  • N-C from carbamoyl phosphate

- C-C-C-N from aspartate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the major difference between the pyrimidine and purine pathways?

A

The pyrimidine ring is built independently and then added to the ribose by a phosphoribosyl transferase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Step 1 of UMP synthesis

A

Glutamine + CO2 + 2 ATP -> carbamoyl phosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Enzyme of step 1 of UMP synthesis

A

Carbamoyl phosphate synthetase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cofactor of step 1 of UMP synthesis

A

Glutamate + 2 ADP + Pi out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where does step 1 of UMP synthesis occur?

A

Cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Step 2 of UMP synthesis

A

Carbamoyl phosphate + aspartate -> N-carbamoylaspartate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Enzyme of step 2 of UMP synthesis

A

Aspartate transcarbamoylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cofactor of step 2 of UMP synthesis

A

Pi out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Step 3 of UMP synthesis

A

N-carbamoylaspartate ->dihydroorotate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Enzyme of step 3 of UMP synthesis

A

Dihydroorotase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cofactor of step 3 of UMP synthesis

A

H2O out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Step 4 of UMP synthesis

A

Dihydroorotate -> orotate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Enzyme of step 4 of UMP synthesis

A

Dihydroorotate dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cofactor of step 4 of UMP synthesis

A

FAD -> FADH2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Step 5 of UMP synthesis

A

Orotate -> orotidine monophosphate

17
Q

Enzyme of step 5 of UMP synthesis

A

Orotate phosphoribosyl transferase

18
Q

Cofactor of step 5 of UMP synthesis

A

PRPP -> PPi

19
Q

Step 6 of UMP synthesis

A

Orotidine monophosphate -> uridine monophosphate

20
Q

Enzyme of step 6 of UMP synthesis

A

Orotidine monophosphate decarboxylase

21
Q

Cofactor of step 6 of UMP synthesis

22
Q

Which type of enzyme adds phosphate groups?

23
Q

Which type of enzyme removes phosphate groups?

A

Pyrophosphate

24
Q

What is the cofactor needed for kinase enzymes?

A

ATP -> ADP

25
Q

What is the cofactor needed for pyrophosphate enzymes?

A

H2O -> PPi

26
Q

Step 1 of CTP/UTP synthesis

A

UMP -> UDP

27
Q

Enzyme of step 1 of CTP/UTP synthesis

A

Monophosphokinase

28
Q

Cofactor of step 1 of CTP/UTP synthesis

A

ATP -> ADP

29
Q

Step 2 of CTP/UTP synthesis

A

UDP -> UTP

30
Q

Enzyme of step 2 of CTP/UTP synthesis

A

Diphosphokinase

31
Q

Cofactor of step 2 of CTP/UTP synthesis

A

ATP -> ADP

32
Q

Step 3 of CTP/UTP synthesis

A

UTP -> CTP

33
Q

Enzyme of step 3 of CTP/UTP synthesis

A

CTP synthetase

34
Q

Cofactor of step 3 of CTP/UTP synthesis

A
  • Glutamine -> glutamate

- ATP -> ADP + Pi

Biochem 2 (40 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions