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Biochem 2 > Lecture 14 - Pyrimidine Synthesis > Flashcards

Lecture 14 - Pyrimidine Synthesis Flashcards

1
Q

Where does each atom of a pyrimidine come from?

A
  • N-C from carbamoyl phosphate

- C-C-C-N from aspartate

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2
Q

What is the major difference between the pyrimidine and purine pathways?

A

The pyrimidine ring is built independently and then added to the ribose by a phosphoribosyl transferase

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3
Q

Step 1 of UMP synthesis

A

Glutamine + CO2 + 2 ATP -> carbamoyl phosphate

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4
Q

Enzyme of step 1 of UMP synthesis

A

Carbamoyl phosphate synthetase

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5
Q

Cofactor of step 1 of UMP synthesis

A

Glutamate + 2 ADP + Pi out

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6
Q

Where does step 1 of UMP synthesis occur?

A

Cytoplasm

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7
Q

Step 2 of UMP synthesis

A

Carbamoyl phosphate + aspartate -> N-carbamoylaspartate

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8
Q

Enzyme of step 2 of UMP synthesis

A

Aspartate transcarbamoylase

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9
Q

Cofactor of step 2 of UMP synthesis

A

Pi out

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10
Q

Step 3 of UMP synthesis

A

N-carbamoylaspartate ->dihydroorotate

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11
Q

Enzyme of step 3 of UMP synthesis

A

Dihydroorotase

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12
Q

Cofactor of step 3 of UMP synthesis

A

H2O out

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13
Q

Step 4 of UMP synthesis

A

Dihydroorotate -> orotate

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14
Q

Enzyme of step 4 of UMP synthesis

A

Dihydroorotate dehydrogenase

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15
Q

Cofactor of step 4 of UMP synthesis

A

FAD -> FADH2

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16
Q

Step 5 of UMP synthesis

A

Orotate -> orotidine monophosphate

17
Q

Enzyme of step 5 of UMP synthesis

A

Orotate phosphoribosyl transferase

18
Q

Cofactor of step 5 of UMP synthesis

A

PRPP -> PPi

19
Q

Step 6 of UMP synthesis

A

Orotidine monophosphate -> uridine monophosphate

20
Q

Enzyme of step 6 of UMP synthesis

A

Orotidine monophosphate decarboxylase

21
Q

Cofactor of step 6 of UMP synthesis

A

CO2 out

22
Q

Which type of enzyme adds phosphate groups?

A

Kinase

23
Q

Which type of enzyme removes phosphate groups?

A

Pyrophosphate

24
Q

What is the cofactor needed for kinase enzymes?

A

ATP -> ADP

25
Q

What is the cofactor needed for pyrophosphate enzymes?

A

H2O -> PPi

26
Q

Step 1 of CTP/UTP synthesis

A

UMP -> UDP

27
Q

Enzyme of step 1 of CTP/UTP synthesis

A

Monophosphokinase

28
Q

Cofactor of step 1 of CTP/UTP synthesis

A

ATP -> ADP

29
Q

Step 2 of CTP/UTP synthesis

A

UDP -> UTP

30
Q

Enzyme of step 2 of CTP/UTP synthesis

A

Diphosphokinase

31
Q

Cofactor of step 2 of CTP/UTP synthesis

A

ATP -> ADP

32
Q

Step 3 of CTP/UTP synthesis

A

UTP -> CTP

33
Q

Enzyme of step 3 of CTP/UTP synthesis

A

CTP synthetase

34
Q

Cofactor of step 3 of CTP/UTP synthesis

A
  • Glutamine -> glutamate

- ATP -> ADP + Pi

Biochem 2 (40 decks)

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