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Biochem 2 > Lecture 14 - Aspartate/Threonine/Isoleucine Synthesis Mechanism > Flashcards

Lecture 14 - Aspartate/Threonine/Isoleucine Synthesis Mechanism Flashcards

1
Q

Step 1

A

Oxaloacetate -> aspartate

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2
Q

Enzyme of step 1

A

Aspartate transaminase

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3
Q

Cofactor of step 1

A
  • PLP

- Glutamate -> alpha-ketoglutarate

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4
Q

Step 2

A

Aspartate -> aspartyl phosphate

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5
Q

Enzyme of step 2

A

Aspartate kinase

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6
Q

Cofactor of step 2

A

ATP -> ADP

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7
Q

Step 3

A

Aspartyl phosphate -> aspartate semi-aldehyde

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8
Q

Enzyme of step 3

A

Aspartate semialdehyde dehydrogenase

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9
Q

Cofactor of step 3

A
  • NADPH + H+ -> NADP+

- H2O -> Pi

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10
Q

Step 4

A

Aspartate semialdehyde -> homoserine

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11
Q

Enzyme of step 4

A

Homoserine dehydrogenase

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12
Q

Cofactor of step 4

A

NADPH + H+ -> NADP+

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13
Q

Step 5

A

Homoserine -> homoserine phosphate

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14
Q

Enzyme of step 5

A

Homoserine kinase

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15
Q

Cofactor of step 5

A

ATP -> ADP

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16
Q

Step 6

A

Homoserine phosphate -> threonine

17
Q

Enzyme of step 6

A

Threonine synthase

18
Q

Cofactor of step 6

19
Q

Step 7

A

Threonine -> alpha-ketobutyrate

20
Q

Enzyme of step 7

A

Threonine dehydratase

21
Q

Cofactor of step 7

22
Q

Step 8

A

Alpha-ketobutyrate -> aceto-alpha-hydroxybutyrate

23
Q

Enzyme of step 8

A

Acetolactate synthase

24
Q

Cofactor of step 8

A

Pyruvate -> CO2

25
Q

Step 9

A

Aceto-alpha-hydroxybutyrate -> dihydroxymethylvalerate

26
Q

Enzyme of step 9

A

Acetolactate isomeroreducatase

27
Q

Cofactor of step 9

A

NADPH + H+ -> NADP+

28
Q

Step 10

A

Dihydroxymethylvalerate -> alpha-ketomethylvalerate

29
Q

Enzyme of step 10

A

Dihydroxy isovalerate dehydratase

30
Q

Cofactor of step 10

31
Q

Step 11

A

Alpha-ketomethylvalerate -> isoleucine

32
Q

Enzyme of step 11

A

Branched chain amino acid transaminase

33
Q

Cofactor of step 11

A
  • PLP

- Glutamate -> alpha-ketoglutarate

34
Q

What is important to note about steps 8-11?

A

Identical to the entire mechanism of valine synthesis

Biochem 2 (40 decks)

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