Lecture 14 - Aspartate/Threonine/Isoleucine Synthesis Mechanism Flashcards
1
Q
Step 1
A
Oxaloacetate -> aspartate
2
Q
Enzyme of step 1
A
Aspartate transaminase
3
Q
Cofactor of step 1
A
- PLP
- Glutamate -> alpha-ketoglutarate
4
Q
Step 2
A
Aspartate -> aspartyl phosphate
5
Q
Enzyme of step 2
A
Aspartate kinase
6
Q
Cofactor of step 2
A
ATP -> ADP
7
Q
Step 3
A
Aspartyl phosphate -> aspartate semi-aldehyde
8
Q
Enzyme of step 3
A
Aspartate semialdehyde dehydrogenase
9
Q
Cofactor of step 3
A
- NADPH + H+ -> NADP+
- H2O -> Pi
10
Q
Step 4
A
Aspartate semialdehyde -> homoserine
11
Q
Enzyme of step 4
A
Homoserine dehydrogenase
12
Q
Cofactor of step 4
A
NADPH + H+ -> NADP+
13
Q
Step 5
A
Homoserine -> homoserine phosphate
14
Q
Enzyme of step 5
A
Homoserine kinase
15
Q
Cofactor of step 5
A
ATP -> ADP
