Lecture 82

Question 1

Atropine is a natural alkaloid and acts as a muscarinic ______. It can be given as treatment for ____ crisis, among other things that you might expect given its mechanism action. Specifically, it can be given in conjunction with a reactivator to treat ________ poisoning.

Answer 1

Atropine is a natural alkaloid and acts as a muscarinic ANTAGONIST. It can be given for treatment of CHOLINERGIC crisis, among other things that you might expect given its antagonistic action.

Question 2

Scopalamine is also a natural alkaloid muscarinic antagonist. It is administered as a transdermal patch (usually seen behind the ear) and it works as an anti______. Keep in mind it actually works through the _____ nervous system, not the periphery.

Answer 2

Scopalamine is also a natural alkaloid. It is administered as a transdermal patch (usally seen behind the ear) and it works as an antiEMETIC. Keep in mind it actually works through the CENTRAL nervous system, not the periphery.

Question 3

Ipatropium is a _____ muscarinic _____, and is used to treat _____ (as it is easily aerosolized.)

Answer 3

Ipatropium is a SYNTHETIC muscarinic ANTAGONIST, and it is used to treat ASTHMA

Question 4

Darifenacin is a muscarinic antagonist, and is selective for ____ (one of the five Muscarinic receptor types.) It is used to treat urinary urge _____ (overactive bladder.)

Answer 4

Darifenacin is a muscarinic antagonist, and is selective for M3. It is used to treat urinary urge INCONTINENCE.

Question 5

Benztropine is a muscarinic antagonist that is used to treat ______, (uncrontrolled shaking.) as it can get into the CNS so well.

Answer 5

Benztropine is a muscarinic antagonist that is used to treat PARKINSON’S.