Lecture 72

Question 1

First broad spectrum antibiotic was ______.

Answer 1

SULFANILIMIDE

Question 2

Physicians, but not Drug Companies, can advocate _____-label use of drugs.

Answer 2

OFF-label (e.g. Beta-blockers for migraines)

Question 3

Absorption, Distribution, Biotransformation, and Excretion are aspects of ________.

Answer 3

PHARMACOKINETICS

Question 4

Local anesthetics block ____ channels by diffusing into the cell and then lodging themselves in the channel.

Answer 4

Block SODIUM

Question 5

____ proteins (e.g. HSPs) bind to intracellular ligand receptors (steroid hormone receptors) and prevent them from being broken down or activated in the absence of ligand.

Answer 5

CHAPERONE

Question 6

Vit K epoxide reductase is an example of non-classical receptors. It is inhibited by _____. Reduced Vit K is required for the synthesis of Vit K-dependent clotting factors and is converted to Vit K epoxide during this synthesis.

Answer 6

Inhibited by WARFARIN

Question 7

Non-receptor mediated action is characterized by a drug acting on something other than a macromolecule. A good example is _____, which neutralizes stomach acid.

Answer 7

BICARBONATE.

Question 8

____ shift in response curve corresponds to higher Potency of a drug, which indicates less is needed to reach max response.

Answer 8

LEFT shift

Question 9

Higher Emax corresponds to higher _____ of a drug. Note that 1/2 Emax may not change.

Answer 9

Higher Emax corresponds to higher EFFICACY of a drug.

Question 10

Antagonists elicit _____ response (Emax = 0) when binding to receptor. Partial agonists elicit _____ response relative to Full Agonists (Full Agonists have _____ Emax value.) Note that partial Agonists can act as _____ of Full Agonists.

Answer 10

Antagonists elicit NO response. Partial Agonists elicit LOWER response relative to Full Agonists (Full Agonists have HIGHEST Emax value.) Partial Agonists can act as ANTAGONISTS of Full Agonists.