Lecture 8- B Cells and Their Response to Antigens

Question 1

How many unique antibody’s?

Answer 1

Infinite

Question 2

What type of immunity is transferred by bodily fluids?

Answer 2

Humoral immune response

Question 3

Which cells are involved in humoral immunity?

Answer 3

Th2, B cells, Plasma cells

Question 4

Which cells produce antibodies?

Answer 4

B cells and plasma cess

Question 5

Which cells activate B cells

Answer 5

Th2

Question 6

What is another name for humoral immunity?

Answer 6

Antibody mediated immunity

Question 7

What markers are on the surface of B cells

Answer 7

CD21, CD19, CD40 and BCR

Question 8

What is the BCR usually

Answer 8

IgM or IgD

Question 9

What do the variable domains on the BCR form?

Answer 9

The antigen binding sites

Question 10

What does the antigen-binding domain become once released from a B cell?

Answer 10

An antibody

Question 11

How many antigen binding sites does one BCR have?

Answer 11

2

Question 12

Are there more BCRs or TCRs per cell

Answer 12

BCRs

Question 13

What are differentiated B cells

Answer 13

Plasma cells and memory cells

Question 14

Are plasma cells long-lived

Answer 14

No

Question 15

What are cancerous plasma cells known as?

Answer 15

Myelomas

Question 16

What happens to an antigen once bound to a BCR?

Answer 16

It is ingested and displayed on MHC II

Question 17

What neutralizes toxins?

Answer 17

Antibodies

Question 18

What kind of immunity is it when antibodies are transferred

Answer 18

Passive immunity

Question 19

What kind of immunity is acquired through exposure to disease causing agents?

Answer 19

Active immunity

Question 20

What type of immunity d vaccines provide?

Answer 20

Active Immunity

Question 21

What is the advantage of passive immunity

Answer 21

It is immediate

Question 22

Which type of immunity involves memory cells?

Answer 22

Active Immunity

Question 23

How do Th2 cells and B cells bind?

Answer 23

TCR binds to MHC II
CD4 binds to B cell
CD40L binds to CD40

Question 24

Can cytokines activate B cells alone?

Answer 24

No

Question 25

What antibodies are produced by memory cells

Answer 25

IgG, IgD, IgA, and IgM

Question 26

What are T-dependent antigens

Answer 26

Protein antigens (toxins) that require T cell binding before immune response

Question 27

Are T-dependent responses slow of fast?

Answer 27

Slow

Question 28

Are T-dependent antibodies high or low affinity

Answer 28

High

Question 29

What do T-dependent antigens stimulate?

Answer 29

Long-lived plasma cells

Question 30

What are T-independent antigens

Answer 30

Antigens that can activate B cells without T cell help

Question 31

Are T-independent responses fast or slow?

Answer 31

Fast

Question 32

Are T-independent antibodies low or high affinity?

Answer 32

low-affinity

Question 33

What antibodies are produced in response to T-independent antigens

Answer 33

IgM

Question 34

What is the role of PRRs on the surface of B and T cells

Answer 34

Chemotaxis

Question 35

What is somatic mutation

Answer 35

The process that increases affinity maturation

Question 36

Where does somatic mutation occur?

Answer 36

THe geminal centers

Question 37

What happens to B cells that do not bind well to antigens during somatic mutation

Answer 37

Apoptosis

Question 38

What type of antigens are T-independent

Answer 38

Polysaccharides

Question 39

Which cells are found in geminal centers to help somatic mutation?

Answer 39

fDC

Question 40

What does somatic mutation select for?

Answer 40

High affinity antibodies