Lecture 12- Hypersensitivity

Question 1

What is a hypersensitivity

Answer 1

Undesirable pathologic lesions triggered by immune response

Question 2

What causes Type I hypersenseitivities?

Answer 2

IgE responding to allergens

Question 3

Cascade of Typpe I hypersensitivity inducing inflammation

Answer 3

Activation of Th2 –> production of IL-4, IL-5, and IL-13 –> Production of IgE –> activation of mast cells and eosinophils –> inflammation

Question 4

What are the effects of histamines, prostaglandins, and leukotrines?

Answer 4

Vasodilation, vascular leak, and Bronchial constriction

Question 5

What is the most extreme form of immediate hypersensitivity?

Answer 5

Anaphylaxis

Question 6

What are the chock organs of anaphylaxis in dogs?

Answer 6

Hepatic veins

Question 7

Which ILs are involved in immediate hypersensitivity?

Answer 7

I-4, IL-5. and IL-13

Question 8

How does IgE sensitize mast cells

Answer 8

By binding to FceR1

Question 9

Which vaccines are most likely to elicit a reaction in dogs

Answer 9

Vaccines that contain fetal calf serum

Question 10

What is given in allergen immunotherapy?

Answer 10

low doses of antigen