Lecture 7 - Histo Of The Heart Flashcards
What are the features of smooth muscle
- fibers are fusiform
- no visible striations
- low, continuous force
How do SM contract
They condense toward focal densities which cause them to shrivel
How are cardiac muscles organized
Short, branched and Y shaped with extensive capillaries
What are intercalated discs
Transverse junctions at the ends of cells that allow passage of electrical current
What are purkinje cells
Modified cardiac muscle cells that act as pacemaker cellsq
What is the fibrous pericardium
Outer covering of dense connective tissue (dense irregular)
What are the parts of the serous pericardium
Parietal layer, visceral layer, and pericardial cavity
What is the parietal layer of serous pericardium
Lines the inner surface of the fibrous pericardium
What is the visceral layer of serous pericardium
Covers the outer surface of the heart
What is the space between the parietal and visceral pericardium
Pericardial cavity
What are the layers of the heart
Epicardium, myocardium, endocardium
What is in the epicardium layer
Visceral layer of serous pericardium
What is in the myocardium
Cardiac muscle
What is in the endocardium
Areolar or loose CT AND endothelium
What cell type is found in endocardium
Simple squamous; flat cells that reduce drag in the area
What portion of the heart covers the valves
Endocardium
What kind of CT is found in epicardium
Mostly loose CT but has pockets of dense
What layer do we find coronary arteries? What are they embedded in?
Epicardium, adipose
Which layer of the heart has mesothelium
Epicardium
What layer is synonymous with visceral pericardium
Epicardium
What is the thickest layer of the heart
Myocardium
What are contained in the myocardium
Cardiomyocytes, nodal cardiomyocytes, myoendocrine cardiomyocytes
What do myoendocrine cardiomyocytes contain
Atrial granules; contain precursor of ANF (atrial natriuretic factor)
What does ANF do?
Targets kidneys to decrease Na and H2O retention
What kind of t-tubules do myocardium have
Diad
What is the orientation of the intercalated disc
Always perpendicular to fibers
What is the adhesion site of the intercalated discs
Fascia adherens
What are actin filaments at the end of terminal sarcomeres that insert into the interdigitating junction
Fascia adherens
What are the 2 types of regions and their subcategories in the interdigitating junction
Transverse
- fascia adherens
- desmosomes
Longitudinal
-gap junction
What are desmosomes?
They are transverse regions that provide anchorage for the intermediate filaments in the cytoskeleton
What are gap junctions
Longitudinal junctions that allow excitation to pass between cells since they are low resistance
What is the difference between t-tubules in cardiac muscle and skeletal muscle
Card
- they are diads
- 1 t-tubule and 1 SR cisterna
Skeletal
- triad
- 1 t-tubule and 2 SR cisternae
What is the purpose of T-tubules
They distribute Ca to all muscle fibers in a bundle which permits uniform contraction