Lecture 12 - Gas Transport Flashcards
where is most of the o2 in blood found
HbA
what is normal Hb concentration
15g /100 ml
what is the saturation of o2 in blood
15g of Hb/100ml*1.39 ml of O2/g Hb = 21ml/100ml
What is PaO2? O2 sat?
100 or 95 mm Hg
97.5%
What is PvO2? Sat?
40 mm Hg
75%
What is the p50 of O2
27 mm Hg
What causes Hb to drop off o2 in tissue
high affinity in high PO2; low aff in tissue (low PO2)
What does a right shift in o2 dissociation mean
decreased affinity
what causes right shift in o2 dissociation
increase temp; increase H+; increase 2,3 DPG, exercise; increase CO2
what causes high 2,3 BPG
chronic hypoxia
what is a left shift
increased affinity for O2
what causes a left shift
lower temp, lower PCO2; less H+
What is A-V O2? what does it mean
the difference of O2 in arterial blood v. venous for an area
shows levels of metabolic demand
what has a high A-V O2? low?
skeletal muscle, kidney
white adipose
what is the respiratory quotient for carbs and fat
1:1 and 7;10
what are the effects of adding more fats to diet or carbs
more fat means lower respiratory quotient; more carbs means higher
what is most of the CO2 in the blood transported as
HCO3-
does arterial or venous side have more carbamino compounds
venous by 6-7x
What is the haldane shift
presence of O2 reduces affinity for CO2
what is the importance of haldane shift
keeps CO2 from associating to Hb in the lungs allowing for efficient gas exchange
