Lecture 12 - Gas Transport

Question 1

where is most of the o2 in blood found

Answer 1

HbA

Question 2

what is normal Hb concentration

Answer 2

15g /100 ml

Question 3

what is the saturation of o2 in blood

Answer 3

15g of Hb/100ml*1.39 ml of O2/g Hb = 21ml/100ml

Question 4

What is PaO2? O2 sat?

Answer 4

100 or 95 mm Hg

97.5%

Question 5

What is PvO2? Sat?

Answer 5

40 mm Hg

75%

Question 6

What is the p50 of O2

Answer 6

27 mm Hg

Question 7

What causes Hb to drop off o2 in tissue

Answer 7

high affinity in high PO2; low aff in tissue (low PO2)

Question 8

What does a right shift in o2 dissociation mean

Answer 8

decreased affinity

Question 9

what causes right shift in o2 dissociation

Answer 9

increase temp; increase H+; increase 2,3 DPG, exercise; increase CO2

Question 10

what causes high 2,3 BPG

Answer 10

chronic hypoxia

Question 11

what is a left shift

Answer 11

increased affinity for O2

Question 12

what causes a left shift

Answer 12

lower temp, lower PCO2; less H+

Question 13

What is A-V O2? what does it mean

Answer 13

the difference of O2 in arterial blood v. venous for an area

shows levels of metabolic demand

Question 14

what has a high A-V O2? low?

Answer 14

skeletal muscle, kidney

white adipose

Question 15

what is the respiratory quotient for carbs and fat

Answer 15

1:1 and 7;10

Question 16

what are the effects of adding more fats to diet or carbs

Answer 16

more fat means lower respiratory quotient; more carbs means higher

Question 17

what is most of the CO2 in the blood transported as

Answer 17

HCO3-

Question 18

does arterial or venous side have more carbamino compounds

Answer 18

venous by 6-7x

Question 19

What is the haldane shift

Answer 19

presence of O2 reduces affinity for CO2

Question 20

what is the importance of haldane shift

Answer 20

keeps CO2 from associating to Hb in the lungs allowing for efficient gas exchange