lecture 6 phamrma of airways Flashcards

1
Q

leukotrienes cause

A

bronchoconstriction

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2
Q

what reveses bronchoconstriction

A

adrenalin

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3
Q

adrenalin works on

A

beta adrenergic receptros

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4
Q

what happens when adrenalin binds to its receptor

A

conformation change and change in the G protein

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5
Q

salbutamol targets

A

beta 2 in the lungs

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6
Q

what are adrenalin and isoprenalin metabolised by

A

catacholamine transferase

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7
Q

exaples of long acting for asthma

A

formetarol and salmetrol

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8
Q

what recruits eosinophils

A

leukotrine B4

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9
Q

what else are eosinophils good against

A

worms

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10
Q

where are alpha receptors

A

arteries and veins

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11
Q

where is beta 1

A

heart

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12
Q

where is beta 2

A

lungs

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13
Q

what is increased with steroids

A

beta 2 receptors

apoptosis of eosinophils

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14
Q

steroids cause

A

cushings

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15
Q

inhaled steroids can..(bad)

A

stunt growth

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16
Q

long acting beta agonist

A

symbicort

17
Q

leukotriene antagonist

A

montelukast

18
Q

cytokines are blocked by

A

steroids

19
Q

theophylline class

A

methyxanthine

20
Q

theophylline action

A

bronchodilator

21
Q

bad about theophylline

A

makes you puke

22
Q

what blocks IL5

A

mepolizumab

23
Q

what recruits eosinophils

A

IL5

24
Q

smoking cessation drug

A

champix

25
Q

long acting muscarinic agonist

A

tiotropium

26
Q

what does tiotropium work on

A

M3 receptors