Lecture 6 Acid Base Balance Flashcards
Normal blood pH
7.35-7.45
Acidic
Increase H+ decreases pH
Alkalotic
Decrease H+ will increase pH
What is pH
% of hydrogen ions in a solution
Acidosis
<7.35 pH
Manifestations: alterations in cardiac contractions
Decreased vascular responses to catecholamines
Dec. response to certain meds
Can lead to loss of consciousness
Alkalosis
> 7.45
Manifestations: impaired neurological function
Impaired muscular function
Tingling sensations, nervousness, muscle twitches
What are the effects of pH?
pH changes affect enzyme function
pH dec then excitability of nerve/muscle cells dec
pH inc then excitability of nerve/muscle cells inc
Respiratory acidosis/alkalosis
Caused by LUNGS or breathing disorders
Results from excess or def. CO2
Metabolic acidosis/alkalosis
Caused by imbalance in the prod. And excretion of acids and bases by the KIDNEYS
results from excess of def of bicarb
Is CO2 and acid or base
Acid and when mixed with water forms carbonic acid
What do the kidneys do?
Excrete nonvolatile acids
Retain/excrete bicarbonate (buffer)
Potassium in relation to acidosis and alkalosis
Acidosis causes hyperkalemia
Alkalosis causes hypokalemia
Compensation for acid-base imbalances
An imbalance of pH caused by one system will be made up by another system
Respiratory: if low pH respiratory Increases, if high pH respiratory dec
Metabolic: if low pH kidneys eliminate H+ and reabsorber bicarb
If high pH kidneys converge H+ and excrete bicarbonate
pH, PaCO2, HCO3 Numbers
pH= 7.35-7.45
PaCO2= 35-45 mm Hg
HCO3= 22-36 mEq/L
PaO2- 80-100
How can we tell we need respiration
The CO2 concentration in blood