Lecture 6

Question 1

B-2 agonists target what?

Answer 1

B2 adrenergic receptors located on autonomic nerve terminals in the smooth muscle of both large and small airways.

Question 1

What do corticosteroids target

Answer 1

target intracellular steroid receptors and reduce transcription of pro-inflammatory mediators within the airway wall.
- airway epithelium
- submucosal gland cells
- inflammatory cells

Question 1

What are the advantages of intrapulmonary Drug Delivery

Answer 1

Faster onset of action, reduced time to peak therapeutic effect, slower clearance of drug deposited in the airways compared to systemic drug clearance

Question 1

another advantage of intrapulmonary drug delivery

Answer 1

minimization of adverse effects and toxicity
- drug is delivered locally to the site of action, a lesser dose is required to attaint he therapeutic effect.

Question 1

two regions that inhaled formulations designed to target

Answer 1

nasal passages and pharynx.

Question 1

D aero is proportional to and can be calculated from

Answer 1

falling velocity.

Question 2

what is the falling velocity

Answer 2

the constant speed a particle will assume when falling after the initial acceleration phase.

Question 2

define aerodynamic diameter

Answer 2

diameter of a perfect spherical object, having a density of 1g/cm3, which has the same falling velocity as the drug particle.

Question 3

ideal particle size range

Answer 3

0.5-5micrometeres